Magnetoencephalography and ictal SPECT in patients with failed epilepsy surgery

Riёm El Tahry, Z. Irene Wang, Aung Thandar, Irina Podkorytova, Balu Krishnan, Simon Tousseyn, Wu Guiyun, Richard C. Burgess, Andreas V. Alexopoulos

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objective: Selected patients with intractable focal epilepsy who have failed a previous epilepsy surgery can become seizure-free with reoperation. Preoperative evaluation is exceedingly challenging in this cohort. We aim to investigate the diagnostic value of two noninvasive approaches, magnetoencephalography (MEG) and ictal single-photon emission computed tomography (SPECT), in patients with failed epilepsy surgery. Methods: We retrospectively included a consecutive cohort of patients who failed prior resective epilepsy surgery, underwent re-evaluation including MEG and ictal SPECT, and had another surgery after the re-evaluation. The relationship between resection and localization from each test was determined, and their association with seizure outcomes was analyzed. Results: A total of 46 patients were included; 21 (46%) were seizure-free at 1-year followup after reoperation. Twenty-seven (58%) had a positive MEG and 31 (67%) had a positive ictal SPECT. The resection of MEG foci was significantly associated with seizure-free outcome (p = 0.002). Overlap of ictal SPECT hyperperfusion zones with resection was significantly associated with seizure-free outcome in the subgroup of patients with injection time ≤20 seconds(p = 0.03), but did not show significant association in the overall cohort (p = 0.46) although all injections were ictal. Patients whose MEG and ictal SPECT were concordant on a sublobar level had a significantly higher chance of seizure freedom (p = 0.05). Conclusions: MEG alone achieved successful localization in patients with failed epilepsy surgery with a statistical significance. Only ictal SPECT with early injection (≤20 seconds) had good localization value. Sublobar concordance between both tests was significantly associated with seizure freedom. SPECT can provide essential information in MEG-negative cases and vice versa. Significance: Our results emphasize the importance of considering a multimodal presurgical evaluation including MEG and SPECT in all patients with a previous failed epilepsy surgery.

Original languageEnglish (US)
Pages (from-to)1651-1657
Number of pages7
JournalClinical Neurophysiology
Volume129
Issue number8
DOIs
StatePublished - Aug 2018

Keywords

  • Epilepsy
  • Failed surgery
  • MEG
  • SPECT

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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  • Cite this

    El Tahry, R., Wang, Z. I., Thandar, A., Podkorytova, I., Krishnan, B., Tousseyn, S., Guiyun, W., Burgess, R. C., & Alexopoulos, A. V. (2018). Magnetoencephalography and ictal SPECT in patients with failed epilepsy surgery. Clinical Neurophysiology, 129(8), 1651-1657. https://doi.org/10.1016/j.clinph.2018.05.010