Maintaining mammalian iron and oxygen homeostasis: Sensors, regulation, and cross-talk

Ameen A. Salahudeen, Richard K. Bruick

Research output: Chapter in Book/Report/Conference proceedingConference contribution

33 Scopus citations

Abstract

Though iron and oxygen are required to sustain essential biological processes, an excess of either can result in oxidative stress. Therefore, mammals tightly regulate cellular and systemic iron and oxygen homeostasis. At the cellular level, the hypoxia-inducible transcription factors (HIFs) are key mediators of oxygen homeostasis through their regulation of genes involved in anaerobic metabolism and oxygen delivery, among others. Iron regulatory proteins (IRPs) largely govern cellular iron homeostasis through their effects on the translation and stability of mRNAs involved in iron uptake, utilization, export, and storage. Here, we describe regulatory factors for each pathway that sense both iron and oxygen availability and coordinate the maintenance of mammalian iron and oxygen homeostasis at both the cellular and systemic levels.

Original languageEnglish (US)
Title of host publicationHypoxia and Consequences From Molecule to Malady
PublisherBlackwell Publishing Inc.
Pages30-38
Number of pages9
ISBN (Print)9781573317733
DOIs
StatePublished - 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1177
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • FBXL5
  • Hemerythrin
  • Hypoxia
  • Hypoxia-inducible factor (HIF)
  • Iron
  • Iron regulatory protein (IRP)
  • Iron- and 2-oxoglutarate-dependent dioxygenase
  • Oxygen

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Salahudeen, A. A., & Bruick, R. K. (2009). Maintaining mammalian iron and oxygen homeostasis: Sensors, regulation, and cross-talk. In Hypoxia and Consequences From Molecule to Malady (pp. 30-38). (Annals of the New York Academy of Sciences; Vol. 1177). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.05038.x