Maintaining mammalian iron and oxygen homeostasis: Sensors, regulation, and cross-talk

Ameen A. Salahudeen, Richard K. Bruick

Research output: Chapter in Book/Report/Conference proceedingConference contribution

33 Scopus citations

Abstract

Though iron and oxygen are required to sustain essential biological processes, an excess of either can result in oxidative stress. Therefore, mammals tightly regulate cellular and systemic iron and oxygen homeostasis. At the cellular level, the hypoxia-inducible transcription factors (HIFs) are key mediators of oxygen homeostasis through their regulation of genes involved in anaerobic metabolism and oxygen delivery, among others. Iron regulatory proteins (IRPs) largely govern cellular iron homeostasis through their effects on the translation and stability of mRNAs involved in iron uptake, utilization, export, and storage. Here, we describe regulatory factors for each pathway that sense both iron and oxygen availability and coordinate the maintenance of mammalian iron and oxygen homeostasis at both the cellular and systemic levels.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages30-38
Number of pages9
Volume1177
DOIs
Publication statusPublished - 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1177
ISSN (Print)00778923
ISSN (Electronic)17496632

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Keywords

  • FBXL5
  • Hemerythrin
  • Hypoxia
  • Hypoxia-inducible factor (HIF)
  • Iron
  • Iron regulatory protein (IRP)
  • Iron- and 2-oxoglutarate-dependent dioxygenase
  • Oxygen

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Salahudeen, A. A., & Bruick, R. K. (2009). Maintaining mammalian iron and oxygen homeostasis: Sensors, regulation, and cross-talk. In Annals of the New York Academy of Sciences (Vol. 1177, pp. 30-38). (Annals of the New York Academy of Sciences; Vol. 1177). https://doi.org/10.1111/j.1749-6632.2009.05038.x