TY - GEN
T1 - Maintaining mammalian iron and oxygen homeostasis
T2 - Sensors, regulation, and cross-talk
AU - Salahudeen, Ameen A.
AU - Bruick, Richard K.
PY - 2009
Y1 - 2009
N2 - Though iron and oxygen are required to sustain essential biological processes, an excess of either can result in oxidative stress. Therefore, mammals tightly regulate cellular and systemic iron and oxygen homeostasis. At the cellular level, the hypoxia-inducible transcription factors (HIFs) are key mediators of oxygen homeostasis through their regulation of genes involved in anaerobic metabolism and oxygen delivery, among others. Iron regulatory proteins (IRPs) largely govern cellular iron homeostasis through their effects on the translation and stability of mRNAs involved in iron uptake, utilization, export, and storage. Here, we describe regulatory factors for each pathway that sense both iron and oxygen availability and coordinate the maintenance of mammalian iron and oxygen homeostasis at both the cellular and systemic levels.
AB - Though iron and oxygen are required to sustain essential biological processes, an excess of either can result in oxidative stress. Therefore, mammals tightly regulate cellular and systemic iron and oxygen homeostasis. At the cellular level, the hypoxia-inducible transcription factors (HIFs) are key mediators of oxygen homeostasis through their regulation of genes involved in anaerobic metabolism and oxygen delivery, among others. Iron regulatory proteins (IRPs) largely govern cellular iron homeostasis through their effects on the translation and stability of mRNAs involved in iron uptake, utilization, export, and storage. Here, we describe regulatory factors for each pathway that sense both iron and oxygen availability and coordinate the maintenance of mammalian iron and oxygen homeostasis at both the cellular and systemic levels.
KW - FBXL5
KW - Hemerythrin
KW - Hypoxia
KW - Hypoxia-inducible factor (HIF)
KW - Iron
KW - Iron regulatory protein (IRP)
KW - Iron- and 2-oxoglutarate-dependent dioxygenase
KW - Oxygen
UR - http://www.scopus.com/inward/record.url?scp=70350357467&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350357467&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.05038.x
DO - 10.1111/j.1749-6632.2009.05038.x
M3 - Conference contribution
C2 - 19845604
AN - SCOPUS:70350357467
SN - 9781573317733
T3 - Annals of the New York Academy of Sciences
SP - 30
EP - 38
BT - Hypoxia and Consequences From Molecule to Malady
PB - Blackwell Publishing Inc.
ER -