Maintenance of the adult Drosophila intestine: all roads lead to homeostasis

Zheng Guo, Elena Lucchetta, Neus Rafel, Benjamin Ohlstein

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


Maintenance of tissue homeostasis is critical in tissues with high turnover such as the intestinal epithelium. The intestinal epithelium is under constant cellular assault due to its digestive functions and its function as a barrier to chemical and bacterial insults. The resulting high rate of cellular turnover necessitates highly controlled mechanisms of regeneration to maintain the integrity of the tissue over the lifetime of the organism. Transient increase in stem cell proliferation is a commonly used and elaborate mechanism to ensure fast and efficient repair of the gut. However, tissue repair is not limited to regulating ISC proliferation, as emerging evidence demonstrates that the Drosophila intestine uses multiple strategies to ensure proper tissue homeostasis that may also extend to other tissues.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalCurrent Opinion in Genetics and Development
StatePublished - Oct 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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