TY - JOUR
T1 - Major depressive disorder and comorbid cardiac disease
T2 - Is there a depressive subtype with greater cardiovascular morbidity? Results from the STAR*D study
AU - Fraguas, Renerio
AU - Iosifescu, Dan V.
AU - Alpert, Jonathan
AU - Wisniewski, Stephen R.
AU - Barkin, Jennifer L.
AU - Trivedi, Madhukar H.
AU - Rush, A. John
AU - Fava, Maurizio
N1 - Funding Information:
This study was funded by the National Institute of Mental Health (NIMH) under Contract N01-MH-90003 to UT Southwestern Medical Center (A.J. Rush, P.I.). The content of this publication does not necessarily reflect the views or policies of the Dept. of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Dr. Fraguas is supported by the National Council for Scientific and Technological Development, CNPq–Brazil , Grant 200776/2003-7E .
PY - 2007
Y1 - 2007
N2 - The authors conducted exploratory analyses to determine whether specific symptoms of major depressive disorder (MDD) are associated with cardiac disease in 4,041 outpatients at baseline in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. MDD was diagnosed with the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition; depressive symptoms were evaluated with the 30-item Inventory of Depressive Symptomatology, Clinician-Rated; and cardiac disease, with the Cumulative Illness Rating Scale. After adjustments for gender, age, ethnicity, education, and employment status, sympathetic arousal and early-morning insomnia were significantly associated with cardiac disease. Prospective studies are warranted to confirm these results.
AB - The authors conducted exploratory analyses to determine whether specific symptoms of major depressive disorder (MDD) are associated with cardiac disease in 4,041 outpatients at baseline in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. MDD was diagnosed with the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition; depressive symptoms were evaluated with the 30-item Inventory of Depressive Symptomatology, Clinician-Rated; and cardiac disease, with the Cumulative Illness Rating Scale. After adjustments for gender, age, ethnicity, education, and employment status, sympathetic arousal and early-morning insomnia were significantly associated with cardiac disease. Prospective studies are warranted to confirm these results.
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U2 - 10.1176/appi.psy.48.5.418
DO - 10.1176/appi.psy.48.5.418
M3 - Article
C2 - 17878501
AN - SCOPUS:34548255886
SN - 0033-3182
VL - 48
SP - 418
EP - 425
JO - Psychosomatics
JF - Psychosomatics
IS - 5
ER -