Major histocompatibility antigens on trophoblast and their regulation

Implications in the maternal-fetal relationship

J. R. Head, B. L. Drake, F. A. Zuckermann

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Recent technological advances have provided methods of detecting antigens encoded by the major histocompatibility complex with greater precision, allowing the expression of such antigens on the components of the placenta to be clarified. Of specific interest is the expression of these antigens on trophoblast cells, the fetal-derived epithelial cells that confront maternal blood and tissues at the maternal-fetal interface. It is now clear that the different trophoblast subpopulations differentially express class I antigens, although none appear to express class II antigens. Class I antigens can be induced by exposure to interferons on some populations but apparently not others, suggesting that the regulation of their expression differs for subpopulations of trophoblast cells, depending on gestational state and location. This restricted expression has important implications for maternal-fetal immune interactions during the different phases of pregnancy and perhaps also bears on physiological functions of the feto-placental unit, such as growth and differentiation.

Original languageEnglish (US)
Pages (from-to)12-18
Number of pages7
JournalAmerican Journal of Reproductive Immunology and Microbiology
Volume15
Issue number1
StatePublished - 1987

Fingerprint

Histocompatibility Antigens
Trophoblasts
Histocompatibility Antigens Class I
Mothers
Antigens
Histocompatibility Antigens Class II
Major Histocompatibility Complex
Interferons
Placenta
Epithelial Cells
Pregnancy
Growth
Population

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynecology

Cite this

Major histocompatibility antigens on trophoblast and their regulation : Implications in the maternal-fetal relationship. / Head, J. R.; Drake, B. L.; Zuckermann, F. A.

In: American Journal of Reproductive Immunology and Microbiology, Vol. 15, No. 1, 1987, p. 12-18.

Research output: Contribution to journalArticle

@article{97f0db4779cb46339eae3e808aa73e65,
title = "Major histocompatibility antigens on trophoblast and their regulation: Implications in the maternal-fetal relationship",
abstract = "Recent technological advances have provided methods of detecting antigens encoded by the major histocompatibility complex with greater precision, allowing the expression of such antigens on the components of the placenta to be clarified. Of specific interest is the expression of these antigens on trophoblast cells, the fetal-derived epithelial cells that confront maternal blood and tissues at the maternal-fetal interface. It is now clear that the different trophoblast subpopulations differentially express class I antigens, although none appear to express class II antigens. Class I antigens can be induced by exposure to interferons on some populations but apparently not others, suggesting that the regulation of their expression differs for subpopulations of trophoblast cells, depending on gestational state and location. This restricted expression has important implications for maternal-fetal immune interactions during the different phases of pregnancy and perhaps also bears on physiological functions of the feto-placental unit, such as growth and differentiation.",
author = "Head, {J. R.} and Drake, {B. L.} and Zuckermann, {F. A.}",
year = "1987",
language = "English (US)",
volume = "15",
pages = "12--18",
journal = "American Journal of Reproductive Immunology",
issn = "8755-8920",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Major histocompatibility antigens on trophoblast and their regulation

T2 - Implications in the maternal-fetal relationship

AU - Head, J. R.

AU - Drake, B. L.

AU - Zuckermann, F. A.

PY - 1987

Y1 - 1987

N2 - Recent technological advances have provided methods of detecting antigens encoded by the major histocompatibility complex with greater precision, allowing the expression of such antigens on the components of the placenta to be clarified. Of specific interest is the expression of these antigens on trophoblast cells, the fetal-derived epithelial cells that confront maternal blood and tissues at the maternal-fetal interface. It is now clear that the different trophoblast subpopulations differentially express class I antigens, although none appear to express class II antigens. Class I antigens can be induced by exposure to interferons on some populations but apparently not others, suggesting that the regulation of their expression differs for subpopulations of trophoblast cells, depending on gestational state and location. This restricted expression has important implications for maternal-fetal immune interactions during the different phases of pregnancy and perhaps also bears on physiological functions of the feto-placental unit, such as growth and differentiation.

AB - Recent technological advances have provided methods of detecting antigens encoded by the major histocompatibility complex with greater precision, allowing the expression of such antigens on the components of the placenta to be clarified. Of specific interest is the expression of these antigens on trophoblast cells, the fetal-derived epithelial cells that confront maternal blood and tissues at the maternal-fetal interface. It is now clear that the different trophoblast subpopulations differentially express class I antigens, although none appear to express class II antigens. Class I antigens can be induced by exposure to interferons on some populations but apparently not others, suggesting that the regulation of their expression differs for subpopulations of trophoblast cells, depending on gestational state and location. This restricted expression has important implications for maternal-fetal immune interactions during the different phases of pregnancy and perhaps also bears on physiological functions of the feto-placental unit, such as growth and differentiation.

UR - http://www.scopus.com/inward/record.url?scp=0023502954&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023502954&partnerID=8YFLogxK

M3 - Article

VL - 15

SP - 12

EP - 18

JO - American Journal of Reproductive Immunology

JF - American Journal of Reproductive Immunology

SN - 8755-8920

IS - 1

ER -