Making a neuron: Cdk5 in embryonic and adult neurogenesis

Sebastian Jessberger, Fred H. Gage, Amelia J. Eisch, Diane C. Lagace

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Cyclin-dependent kinase 5 (Cdk5) has been implicated in the migration, maturation and survival of neurons born during embryonic development. New evidence suggests that Cdk5 has comparable but also distinct functions in adult neurogenesis. Here we summarize accumulating evidence on the role of Cdk5 in regulation of the cell cycle, migration, survival, maturation and neuronal integration. We specifically highlight the many similarities and few tantalizing differences in the roles of Cdk5 in the embryonic and adult brain. We discuss the signaling pathways that might contribute to Cdk5 action in regulating embryonic and adult neurogenesis, highlighting future research directions that will help to clarify the mechanisms underlying lifelong neurogenesis in the mammalian brain.

Original languageEnglish (US)
Pages (from-to)575-582
Number of pages8
JournalTrends in Neurosciences
Volume32
Issue number11
DOIs
StatePublished - Nov 2009

Fingerprint

Cyclin-Dependent Kinase 5
Neurogenesis
Neurons
Brain
Embryonic Development
Cell Movement
Cell Cycle

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Making a neuron : Cdk5 in embryonic and adult neurogenesis. / Jessberger, Sebastian; Gage, Fred H.; Eisch, Amelia J.; Lagace, Diane C.

In: Trends in Neurosciences, Vol. 32, No. 11, 11.2009, p. 575-582.

Research output: Contribution to journalArticle

Jessberger, Sebastian ; Gage, Fred H. ; Eisch, Amelia J. ; Lagace, Diane C. / Making a neuron : Cdk5 in embryonic and adult neurogenesis. In: Trends in Neurosciences. 2009 ; Vol. 32, No. 11. pp. 575-582.
@article{33870f5571614e85b4367d4e648f7336,
title = "Making a neuron: Cdk5 in embryonic and adult neurogenesis",
abstract = "Cyclin-dependent kinase 5 (Cdk5) has been implicated in the migration, maturation and survival of neurons born during embryonic development. New evidence suggests that Cdk5 has comparable but also distinct functions in adult neurogenesis. Here we summarize accumulating evidence on the role of Cdk5 in regulation of the cell cycle, migration, survival, maturation and neuronal integration. We specifically highlight the many similarities and few tantalizing differences in the roles of Cdk5 in the embryonic and adult brain. We discuss the signaling pathways that might contribute to Cdk5 action in regulating embryonic and adult neurogenesis, highlighting future research directions that will help to clarify the mechanisms underlying lifelong neurogenesis in the mammalian brain.",
author = "Sebastian Jessberger and Gage, {Fred H.} and Eisch, {Amelia J.} and Lagace, {Diane C.}",
year = "2009",
month = "11",
doi = "10.1016/j.tins.2009.07.002",
language = "English (US)",
volume = "32",
pages = "575--582",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Making a neuron

T2 - Cdk5 in embryonic and adult neurogenesis

AU - Jessberger, Sebastian

AU - Gage, Fred H.

AU - Eisch, Amelia J.

AU - Lagace, Diane C.

PY - 2009/11

Y1 - 2009/11

N2 - Cyclin-dependent kinase 5 (Cdk5) has been implicated in the migration, maturation and survival of neurons born during embryonic development. New evidence suggests that Cdk5 has comparable but also distinct functions in adult neurogenesis. Here we summarize accumulating evidence on the role of Cdk5 in regulation of the cell cycle, migration, survival, maturation and neuronal integration. We specifically highlight the many similarities and few tantalizing differences in the roles of Cdk5 in the embryonic and adult brain. We discuss the signaling pathways that might contribute to Cdk5 action in regulating embryonic and adult neurogenesis, highlighting future research directions that will help to clarify the mechanisms underlying lifelong neurogenesis in the mammalian brain.

AB - Cyclin-dependent kinase 5 (Cdk5) has been implicated in the migration, maturation and survival of neurons born during embryonic development. New evidence suggests that Cdk5 has comparable but also distinct functions in adult neurogenesis. Here we summarize accumulating evidence on the role of Cdk5 in regulation of the cell cycle, migration, survival, maturation and neuronal integration. We specifically highlight the many similarities and few tantalizing differences in the roles of Cdk5 in the embryonic and adult brain. We discuss the signaling pathways that might contribute to Cdk5 action in regulating embryonic and adult neurogenesis, highlighting future research directions that will help to clarify the mechanisms underlying lifelong neurogenesis in the mammalian brain.

UR - http://www.scopus.com/inward/record.url?scp=70350120731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350120731&partnerID=8YFLogxK

U2 - 10.1016/j.tins.2009.07.002

DO - 10.1016/j.tins.2009.07.002

M3 - Article

C2 - 19782409

AN - SCOPUS:70350120731

VL - 32

SP - 575

EP - 582

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 11

ER -