Malachite Green Derivatives for Two-Photon RNA Detection

Jacques Lux, Eduardo José Peña, Frédéric Bolze, Manfred Heinlein, Jean François Nicoud

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The design, preparation and characterisation of a library of malachite green (MG) derivatives for two-photon RNA labelling is described. Some of these MG derivatives exhibit an increased affinity for an MG-aptamer, as well as improved two-photon sensitivity when compared to the classical malachite green chloride. The underlying mechanisms and potential benefits for in vivo RNA visualisation are discussed.

Original languageEnglish (US)
Pages (from-to)1206-1213
Number of pages8
JournalChemBioChem
Volume13
Issue number8
DOIs
StatePublished - May 2012

Keywords

  • Aptamers
  • Fluorescent probes
  • Malachite green
  • RNA visualization
  • Two-photon absorption

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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