Malachite Green Derivatives for Two-Photon RNA Detection

Jacques Lux; Eduardo José Peña; Frédéric Bolze; Manfred Heinlein; Jean François Nicoud

doi:10.1002/cbic.201100747

Malachite Green Derivatives for Two-Photon RNA Detection

Jacques Lux, Eduardo José Peña, Frédéric Bolze, Manfred Heinlein, Jean François Nicoud

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The design, preparation and characterisation of a library of malachite green (MG) derivatives for two-photon RNA labelling is described. Some of these MG derivatives exhibit an increased affinity for an MG-aptamer, as well as improved two-photon sensitivity when compared to the classical malachite green chloride. The underlying mechanisms and potential benefits for in vivo RNA visualisation are discussed.

Original language	English (US)
Pages (from-to)	1206-1213
Number of pages	8
Journal	ChemBioChem
Volume	13
Issue number	8
DOIs	https://doi.org/10.1002/cbic.201100747
State	Published - May 2012

Keywords

Aptamers
Fluorescent probes
Malachite green
RNA visualization
Two-photon absorption

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

Access to Document

10.1002/cbic.201100747

Cite this

@article{2d601f3a929e49a5a6152762f6c0f324,

title = "Malachite Green Derivatives for Two-Photon RNA Detection",

abstract = "The design, preparation and characterisation of a library of malachite green (MG) derivatives for two-photon RNA labelling is described. Some of these MG derivatives exhibit an increased affinity for an MG-aptamer, as well as improved two-photon sensitivity when compared to the classical malachite green chloride. The underlying mechanisms and potential benefits for in vivo RNA visualisation are discussed.",

keywords = "Aptamers, Fluorescent probes, Malachite green, RNA visualization, Two-photon absorption",

author = "Jacques Lux and Pe{\~n}a, {Eduardo Jos{\'e}} and Fr{\'e}d{\'e}ric Bolze and Manfred Heinlein and Nicoud, {Jean Fran{\c c}ois}",

year = "2012",

month = may,

doi = "10.1002/cbic.201100747",

language = "English (US)",

volume = "13",

pages = "1206--1213",

journal = "ChemBioChem",

issn = "1439-4227",

publisher = "Wiley-VCH Verlag",

number = "8",

}

TY - JOUR

T1 - Malachite Green Derivatives for Two-Photon RNA Detection

AU - Lux, Jacques

AU - Peña, Eduardo José

AU - Bolze, Frédéric

AU - Heinlein, Manfred

AU - Nicoud, Jean François

PY - 2012/5

Y1 - 2012/5

N2 - The design, preparation and characterisation of a library of malachite green (MG) derivatives for two-photon RNA labelling is described. Some of these MG derivatives exhibit an increased affinity for an MG-aptamer, as well as improved two-photon sensitivity when compared to the classical malachite green chloride. The underlying mechanisms and potential benefits for in vivo RNA visualisation are discussed.

AB - The design, preparation and characterisation of a library of malachite green (MG) derivatives for two-photon RNA labelling is described. Some of these MG derivatives exhibit an increased affinity for an MG-aptamer, as well as improved two-photon sensitivity when compared to the classical malachite green chloride. The underlying mechanisms and potential benefits for in vivo RNA visualisation are discussed.

KW - Aptamers

KW - Fluorescent probes

KW - Malachite green

KW - RNA visualization

KW - Two-photon absorption

UR - http://www.scopus.com/inward/record.url?scp=84861431300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861431300&partnerID=8YFLogxK

U2 - 10.1002/cbic.201100747

DO - 10.1002/cbic.201100747

M3 - Article

C2 - 22549874

AN - SCOPUS:84861431300

SN - 1439-4227

VL - 13

SP - 1206

EP - 1213

JO - ChemBioChem

JF - ChemBioChem

IS - 8

ER -

Malachite Green Derivatives for Two-Photon RNA Detection

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this