Male and female isoenzymes of steroid 5α-reductase

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

There are two steroid 5α-reductase isoenzymes, designated type 1 and type 2, in mammals and recent experiments show that each plays a unique physiological role. In this article, the hypothesis is developed that the type 1 gene specifies a female isoenzyme, whereas the type 2 gene specifies a male isoenzyme. This idea results from the following observations. First, mutation of the 5α-reductase type 1 gene in mice affects reproduction in females by decreasing fecundity and blocking parturition, but has no effect on reproduction in males. Second, mutation of the 5α-reductase type 2 gene in mice and men prevents proper virilization but does not affect development or reproductive function in females. Analyses of these diverse phenotypes indicate that the isoenzymes catalyse both anabolic and catabolic reactions in steroid hormone metabolism.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalReviews of Reproduction
Volume4
Issue number3
DOIs
StatePublished - 1999

Fingerprint

Isoenzymes
steroids
isozymes
Oxidoreductases
Steroids
Genes
Reproduction
genes
steroid metabolism
masculinization
Virilism
hormone metabolism
mutation
childbirth
Mutation
mice
steroid hormones
Fertility
Mammals
fecundity

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Agricultural and Biological Sciences(all)

Cite this

Male and female isoenzymes of steroid 5α-reductase. / Mahendroo, Mala S.; Russell, David W.

In: Reviews of Reproduction, Vol. 4, No. 3, 1999, p. 179-183.

Research output: Contribution to journalArticle

@article{2f89636f80ea4c20974befd804139816,
title = "Male and female isoenzymes of steroid 5α-reductase",
abstract = "There are two steroid 5α-reductase isoenzymes, designated type 1 and type 2, in mammals and recent experiments show that each plays a unique physiological role. In this article, the hypothesis is developed that the type 1 gene specifies a female isoenzyme, whereas the type 2 gene specifies a male isoenzyme. This idea results from the following observations. First, mutation of the 5α-reductase type 1 gene in mice affects reproduction in females by decreasing fecundity and blocking parturition, but has no effect on reproduction in males. Second, mutation of the 5α-reductase type 2 gene in mice and men prevents proper virilization but does not affect development or reproductive function in females. Analyses of these diverse phenotypes indicate that the isoenzymes catalyse both anabolic and catabolic reactions in steroid hormone metabolism.",
author = "Mahendroo, {Mala S.} and Russell, {David W.}",
year = "1999",
doi = "10.1530/ror.0.0040179",
language = "English (US)",
volume = "4",
pages = "179--183",
journal = "Reproduction",
issn = "1470-1626",
publisher = "BioScientifica Ltd.",
number = "3",

}

TY - JOUR

T1 - Male and female isoenzymes of steroid 5α-reductase

AU - Mahendroo, Mala S.

AU - Russell, David W.

PY - 1999

Y1 - 1999

N2 - There are two steroid 5α-reductase isoenzymes, designated type 1 and type 2, in mammals and recent experiments show that each plays a unique physiological role. In this article, the hypothesis is developed that the type 1 gene specifies a female isoenzyme, whereas the type 2 gene specifies a male isoenzyme. This idea results from the following observations. First, mutation of the 5α-reductase type 1 gene in mice affects reproduction in females by decreasing fecundity and blocking parturition, but has no effect on reproduction in males. Second, mutation of the 5α-reductase type 2 gene in mice and men prevents proper virilization but does not affect development or reproductive function in females. Analyses of these diverse phenotypes indicate that the isoenzymes catalyse both anabolic and catabolic reactions in steroid hormone metabolism.

AB - There are two steroid 5α-reductase isoenzymes, designated type 1 and type 2, in mammals and recent experiments show that each plays a unique physiological role. In this article, the hypothesis is developed that the type 1 gene specifies a female isoenzyme, whereas the type 2 gene specifies a male isoenzyme. This idea results from the following observations. First, mutation of the 5α-reductase type 1 gene in mice affects reproduction in females by decreasing fecundity and blocking parturition, but has no effect on reproduction in males. Second, mutation of the 5α-reductase type 2 gene in mice and men prevents proper virilization but does not affect development or reproductive function in females. Analyses of these diverse phenotypes indicate that the isoenzymes catalyse both anabolic and catabolic reactions in steroid hormone metabolism.

UR - http://www.scopus.com/inward/record.url?scp=0032826077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032826077&partnerID=8YFLogxK

U2 - 10.1530/ror.0.0040179

DO - 10.1530/ror.0.0040179

M3 - Article

VL - 4

SP - 179

EP - 183

JO - Reproduction

JF - Reproduction

SN - 1470-1626

IS - 3

ER -