Male breast cancer as a second primary cancer: Increased risk following lymphoma

Deborah E. Farr, Alexandra Thomas, Seema Ahsan Khan, Mary C. Schroeder

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background. Male breast cancer (MBC) as a second primary cancer (SPC) has a known association with priorMBC. However, its association with non-breast index malignancies, relative to population risk, has not been previously reported. Materials and Methods. Using Surveillance, Epidemiology, and End Results program (9 catchment area) data, we identified MBCs diagnosed from 1973-2012 as their SPC. Information regarding the index malignancy was also obtained. Standardized incidence ratios (SIR) ofMBC as SPC were estimated, along with incidence rates and trends. Kaplan-Meier curves were used to estimate survival. Results. Over a 38-year period, 464 MBCs were identified as SPC. The most common index malignancies were breast (SIR 30.86, 95% confidence interval [CI] 21.50-42.92, p< .001), lymphoma (SIR 1.58, 95% CI 1.08-2.22, p5.014), melanoma (SIR 1.26, 95% CI 0.80-1.89), urinary (SIR 1.05, 95% CI 0.74-1.43), colorectal (SIR 0.94, 95% CI 0.69-1.24), and prostate (SIR 0.93 95% CI 0.81-1.07). Apart from the known association with prior breast cancer, the only significant association was with lymphoma as an index cancer, although not significant with a Bonferroni correction. From 1975-2012, incidence of breast cancer as a first cancer increased at an annual percentage change of 1.3% while breast cancer as a SPC increased at 4.7% (both p values < .001). Conclusion.Male breast cancer as a SPC has increasedmarkedly over 4 decades. Men with a history of lymphoma may experience higher-than-expected rates of breast SPC. These observations warrant further research, and suggest possible etiologic connections with disease biology, prior therapy, or genetics.

Original languageEnglish (US)
Pages (from-to)895-900
Number of pages6
JournalOncologist
Volume22
Issue number8
DOIs
StatePublished - Aug 1 2017

Fingerprint

Male Breast Neoplasms
Second Primary Neoplasms
Lymphoma
Incidence
Confidence Intervals
Breast Neoplasms
Neoplasms
SEER Program
Genetic Therapy
Prostate
Melanoma
Breast

Keywords

  • Incidence
  • Male breast neoplasms
  • Second primary neoplasm
  • Surveillance, epidemiology, and end results program

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Male breast cancer as a second primary cancer : Increased risk following lymphoma. / Farr, Deborah E.; Thomas, Alexandra; Khan, Seema Ahsan; Schroeder, Mary C.

In: Oncologist, Vol. 22, No. 8, 01.08.2017, p. 895-900.

Research output: Contribution to journalArticle

Farr, Deborah E. ; Thomas, Alexandra ; Khan, Seema Ahsan ; Schroeder, Mary C. / Male breast cancer as a second primary cancer : Increased risk following lymphoma. In: Oncologist. 2017 ; Vol. 22, No. 8. pp. 895-900.
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abstract = "Background. Male breast cancer (MBC) as a second primary cancer (SPC) has a known association with priorMBC. However, its association with non-breast index malignancies, relative to population risk, has not been previously reported. Materials and Methods. Using Surveillance, Epidemiology, and End Results program (9 catchment area) data, we identified MBCs diagnosed from 1973-2012 as their SPC. Information regarding the index malignancy was also obtained. Standardized incidence ratios (SIR) ofMBC as SPC were estimated, along with incidence rates and trends. Kaplan-Meier curves were used to estimate survival. Results. Over a 38-year period, 464 MBCs were identified as SPC. The most common index malignancies were breast (SIR 30.86, 95{\%} confidence interval [CI] 21.50-42.92, p< .001), lymphoma (SIR 1.58, 95{\%} CI 1.08-2.22, p5.014), melanoma (SIR 1.26, 95{\%} CI 0.80-1.89), urinary (SIR 1.05, 95{\%} CI 0.74-1.43), colorectal (SIR 0.94, 95{\%} CI 0.69-1.24), and prostate (SIR 0.93 95{\%} CI 0.81-1.07). Apart from the known association with prior breast cancer, the only significant association was with lymphoma as an index cancer, although not significant with a Bonferroni correction. From 1975-2012, incidence of breast cancer as a first cancer increased at an annual percentage change of 1.3{\%} while breast cancer as a SPC increased at 4.7{\%} (both p values < .001). Conclusion.Male breast cancer as a SPC has increasedmarkedly over 4 decades. Men with a history of lymphoma may experience higher-than-expected rates of breast SPC. These observations warrant further research, and suggest possible etiologic connections with disease biology, prior therapy, or genetics.",
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N2 - Background. Male breast cancer (MBC) as a second primary cancer (SPC) has a known association with priorMBC. However, its association with non-breast index malignancies, relative to population risk, has not been previously reported. Materials and Methods. Using Surveillance, Epidemiology, and End Results program (9 catchment area) data, we identified MBCs diagnosed from 1973-2012 as their SPC. Information regarding the index malignancy was also obtained. Standardized incidence ratios (SIR) ofMBC as SPC were estimated, along with incidence rates and trends. Kaplan-Meier curves were used to estimate survival. Results. Over a 38-year period, 464 MBCs were identified as SPC. The most common index malignancies were breast (SIR 30.86, 95% confidence interval [CI] 21.50-42.92, p< .001), lymphoma (SIR 1.58, 95% CI 1.08-2.22, p5.014), melanoma (SIR 1.26, 95% CI 0.80-1.89), urinary (SIR 1.05, 95% CI 0.74-1.43), colorectal (SIR 0.94, 95% CI 0.69-1.24), and prostate (SIR 0.93 95% CI 0.81-1.07). Apart from the known association with prior breast cancer, the only significant association was with lymphoma as an index cancer, although not significant with a Bonferroni correction. From 1975-2012, incidence of breast cancer as a first cancer increased at an annual percentage change of 1.3% while breast cancer as a SPC increased at 4.7% (both p values < .001). Conclusion.Male breast cancer as a SPC has increasedmarkedly over 4 decades. Men with a history of lymphoma may experience higher-than-expected rates of breast SPC. These observations warrant further research, and suggest possible etiologic connections with disease biology, prior therapy, or genetics.

AB - Background. Male breast cancer (MBC) as a second primary cancer (SPC) has a known association with priorMBC. However, its association with non-breast index malignancies, relative to population risk, has not been previously reported. Materials and Methods. Using Surveillance, Epidemiology, and End Results program (9 catchment area) data, we identified MBCs diagnosed from 1973-2012 as their SPC. Information regarding the index malignancy was also obtained. Standardized incidence ratios (SIR) ofMBC as SPC were estimated, along with incidence rates and trends. Kaplan-Meier curves were used to estimate survival. Results. Over a 38-year period, 464 MBCs were identified as SPC. The most common index malignancies were breast (SIR 30.86, 95% confidence interval [CI] 21.50-42.92, p< .001), lymphoma (SIR 1.58, 95% CI 1.08-2.22, p5.014), melanoma (SIR 1.26, 95% CI 0.80-1.89), urinary (SIR 1.05, 95% CI 0.74-1.43), colorectal (SIR 0.94, 95% CI 0.69-1.24), and prostate (SIR 0.93 95% CI 0.81-1.07). Apart from the known association with prior breast cancer, the only significant association was with lymphoma as an index cancer, although not significant with a Bonferroni correction. From 1975-2012, incidence of breast cancer as a first cancer increased at an annual percentage change of 1.3% while breast cancer as a SPC increased at 4.7% (both p values < .001). Conclusion.Male breast cancer as a SPC has increasedmarkedly over 4 decades. Men with a history of lymphoma may experience higher-than-expected rates of breast SPC. These observations warrant further research, and suggest possible etiologic connections with disease biology, prior therapy, or genetics.

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