Abstract
The assessment of behaviral development in the progeny of males exposed to known mutagenic chemicals is a potentially sensitive endpoint for detecting transmissible abonormalities. A genetic components is demonstrated as these behavioral abnormalities can also be passed on to the F2 generation. In this review, experimental studies exploring transmission of behavioral deficits from paternal exposure to drugs, chemicals and radiation are addressed. Additionally included is a brief synopis of recent work perfomed in our laboratory investigating such abnormalities in offspring from male rats exposed to ionizing radiations. The implications of these behavioral endpoints to humans is also discussed.
Original language | English (US) |
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Pages (from-to) | 213-229 |
Number of pages | 17 |
Journal | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
Volume | 229 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1990 |
Keywords
- Behaviortal abnormalities
- Developmental deficits
- Ionizing radiation
- Male-mediated effects
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Health, Toxicology and Mutagenesis