Malignant glioma: Lessons from genomics, mouse models, and stem cells

Jian Chen, Renée M. McKay, Luis F. Parada

Research output: Contribution to journalReview article

316 Scopus citations

Abstract

Eighty percent of malignant tumors that develop in the central nervous system are malignant gliomas, which are essentially incurable. Here, we discuss how recent sequencing studies are identifying unexpected drivers of gliomagenesis, including mutations in isocitrate dehydrogenase 1 and the NF-κB pathway, and how genome-wide analyses are reshaping the classification schemes for tumors and enhancing prognostic value of molecular markers. We discuss the controversies surrounding glioma stem cells and explore how the integration of new molecular data allows for the generation of more informative animal models to advance our knowledge of glioma's origin, progression, and treatment.

Original languageEnglish (US)
Pages (from-to)36-47
Number of pages12
JournalCell
Volume149
Issue number1
DOIs
StatePublished - Mar 30 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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