Abstract
Malignant salivary gland tumours of the larynx are very rare, with limited reports of clinical outcomes. We present the decade-long experience of a single institution. A 10-year retrospective chart review of a tertiary head and neck cancer centre was performed. Index patients were identified from a review of a pathology database, and reviewed by a head and neck pathologist. Patient demographics, presenting signs and symptoms, treatment modalities and clinical outcomes were extracted from electronic medical records. Six patients were included, with an age range of 44 to 69. All six had malignant laryngeal salivary gland tumours. Pathologies included: three adenoid cystic carcinoma (2 supraglottic, 1 subglottic), one mucoepidermoid carcinoma (supraglottic), one epithelial-myoepithelial carcinoma (supraglottic) and one adenocarcinoma (transglottic). All were treated with surgery (2 endolaryngeal, 4 open) and five of six with the addition of adjuvant therapy (4 radiotherapy, 1 concurrent chemoradiation). One patient had smoking history; no patients had significant alcohol history. With 4.5 years of median follow-up, none of the patients has had recurrence or local/distant metastasis. Salivary gland tumours of the larynx present in mid to late-age, and can be successfully managed with a multi-modality approach, resulting in excellent local and regional control rates.
| Original language | Italian |
|---|---|
| Pages (from-to) | 289-294 |
| Number of pages | 6 |
| Journal | Acta Otorhinolaryngologica Italica |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 2016 |
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Keywords
- Cancer
- Chemotherapy
- Larynx
- Partial laryngectomy
- Salivary
- Surgery
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Tumori maligni delle ghiandole salivari della laringe : Un’unica review istituzionale. / Karatayli-Ozgursoy, S.; Bishop, J. A.; Hillel, A. T.; Akst, L. M.; Best, S. R.
In: Acta Otorhinolaryngologica Italica, Vol. 36, No. 4, 01.01.2016, p. 289-294.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tumori maligni delle ghiandole salivari della laringe
T2 - Un’unica review istituzionale
AU - Karatayli-Ozgursoy, S.
AU - Bishop, J. A.
AU - Hillel, A. T.
AU - Akst, L. M.
AU - Best, S. R.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Malignant salivary gland tumours of the larynx are very rare, with limited reports of clinical outcomes. We present the decade-long experience of a single institution. A 10-year retrospective chart review of a tertiary head and neck cancer centre was performed. Index patients were identified from a review of a pathology database, and reviewed by a head and neck pathologist. Patient demographics, presenting signs and symptoms, treatment modalities and clinical outcomes were extracted from electronic medical records. Six patients were included, with an age range of 44 to 69. All six had malignant laryngeal salivary gland tumours. Pathologies included: three adenoid cystic carcinoma (2 supraglottic, 1 subglottic), one mucoepidermoid carcinoma (supraglottic), one epithelial-myoepithelial carcinoma (supraglottic) and one adenocarcinoma (transglottic). All were treated with surgery (2 endolaryngeal, 4 open) and five of six with the addition of adjuvant therapy (4 radiotherapy, 1 concurrent chemoradiation). One patient had smoking history; no patients had significant alcohol history. With 4.5 years of median follow-up, none of the patients has had recurrence or local/distant metastasis. Salivary gland tumours of the larynx present in mid to late-age, and can be successfully managed with a multi-modality approach, resulting in excellent local and regional control rates.
AB - Malignant salivary gland tumours of the larynx are very rare, with limited reports of clinical outcomes. We present the decade-long experience of a single institution. A 10-year retrospective chart review of a tertiary head and neck cancer centre was performed. Index patients were identified from a review of a pathology database, and reviewed by a head and neck pathologist. Patient demographics, presenting signs and symptoms, treatment modalities and clinical outcomes were extracted from electronic medical records. Six patients were included, with an age range of 44 to 69. All six had malignant laryngeal salivary gland tumours. Pathologies included: three adenoid cystic carcinoma (2 supraglottic, 1 subglottic), one mucoepidermoid carcinoma (supraglottic), one epithelial-myoepithelial carcinoma (supraglottic) and one adenocarcinoma (transglottic). All were treated with surgery (2 endolaryngeal, 4 open) and five of six with the addition of adjuvant therapy (4 radiotherapy, 1 concurrent chemoradiation). One patient had smoking history; no patients had significant alcohol history. With 4.5 years of median follow-up, none of the patients has had recurrence or local/distant metastasis. Salivary gland tumours of the larynx present in mid to late-age, and can be successfully managed with a multi-modality approach, resulting in excellent local and regional control rates.
KW - Cancer
KW - Chemotherapy
KW - Larynx
KW - Partial laryngectomy
KW - Salivary
KW - Surgery
UR - http://www.scopus.com/inward/record.url?scp=84990857927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84990857927&partnerID=8YFLogxK
U2 - 10.14639/0392-100X-807
DO - 10.14639/0392-100X-807
M3 - Article
C2 - 27734981
AN - SCOPUS:84990857927
VL - 36
SP - 289
EP - 294
JO - Acta Otorhinolaryngologica Italica
JF - Acta Otorhinolaryngologica Italica
SN - 0392-100X
IS - 4
ER -