Malonyl-CoA

The regulator of fatty acid synthesis and oxidation

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

In the catabolic state with no food intake, the liver generates ketones by breaking down fatty acids. During the nocturnal fast or longer starvation periods, this protects the brain, which cannot oxidize fatty acids. In 1977, we published a study in the JCI noting the surprising realization that malonyl-CoA, the substrate of fatty acid synthesis, was also an inhibitor of fatty acid oxidation. Subsequent experiments have borne out this finding and furthered our understanding of molecular metabolism.

Original languageEnglish (US)
Pages (from-to)1958-1959
Number of pages2
JournalJournal of Clinical Investigation
Volume122
Issue number6
DOIs
StatePublished - Jun 1 2012

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Malonyl Coenzyme A
Fatty Acids
Starvation
Ketones
Eating
Liver
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Malonyl-CoA : The regulator of fatty acid synthesis and oxidation. / Foster, Daniel W.

In: Journal of Clinical Investigation, Vol. 122, No. 6, 01.06.2012, p. 1958-1959.

Research output: Contribution to journalArticle

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