Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons

François Guillemot, Li Ching Lo, Jane E. Johnson, Anna Auerbach, David J. Anderson, Alexandra L. Joyner

Research output: Contribution to journalArticle

875 Citations (Scopus)

Abstract

The mouse Mash-1 gene, like its Drosophila homologs of the achaete-scute complex (AS-C), encodes a transcription factor expressed in neural precursors. We created a null allele of this gene by homologous recombination in embryonic stem cells. Mice homozygous for the mutation die at birth with apparent breathing and feeding defects. The brain and spinal cord of the mutants appear normal, but their olfactory epithelium and sympathetic, parasympathetic, and enteric ganglia are severely affected. In the olfactory epithelium, neuronal progenitors die at an early stage, whereas the nonneuronal supporting cells are present. In sympathetic ganglia, the mutation arrests the development of neuronal precursors, preventing the generation of sympathetic neurons, but does not affect glial precursor cells. These observations suggest that Mash-1, like its Drosophila homologs of the AS-C, controls a basic operation in development of neuronal progenitors in distinct neural lineages.

Original languageEnglish (US)
Pages (from-to)463-476
Number of pages14
JournalCell
Volume75
Issue number3
DOIs
StatePublished - Nov 5 1993

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Olfactory Mucosa
Drosophila
Neurons
Parasympathetic Ganglia
Genes
Sympathetic Ganglia
Mutation
Homologous Recombination
Embryonic Stem Cells
Stem cells
Neuroglia
Brain
Spinal Cord
Respiration
Transcription Factors
Alleles
Parturition
Defects

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. / Guillemot, François; Lo, Li Ching; Johnson, Jane E.; Auerbach, Anna; Anderson, David J.; Joyner, Alexandra L.

In: Cell, Vol. 75, No. 3, 05.11.1993, p. 463-476.

Research output: Contribution to journalArticle

Guillemot, François ; Lo, Li Ching ; Johnson, Jane E. ; Auerbach, Anna ; Anderson, David J. ; Joyner, Alexandra L. / Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. In: Cell. 1993 ; Vol. 75, No. 3. pp. 463-476.
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