Management of infections caused by antibiotic-resistant Streptococcus pneumoniae

Ian R. Friedland, George H. Mccracken

Research output: Contribution to journalArticle

542 Citations (Scopus)

Abstract

The increasing resistance of S. pneumoniae to antimicrobial agents is a cause for concern. Although a number of therapeutic strategies are possible, local patterns of resistance must be considered. It is essential to determine the susceptibility of individual strains to penicillin and other antimicrobial agents that could be used for therapy. Communication between the clinician and the laboratory is vital to determine the best therapeutic options. The recent recognition of cephalosporin-resistant strains emphasizes the need to determine susceptibility to cephalosporins. Clinical laboratories should be aware of the recently proposed changes in the definition of cephalosporin resistance, and clinicians need to be aware of how these changes affect the choice of antibiotic therapy. Until pneumococcal disease can be effectively prevented, we can expect resistant pneumococcal infections to continue to pose therapeutic difficulties.

Original languageEnglish (US)
Pages (from-to)377-382
Number of pages6
JournalNew England Journal of Medicine
Volume331
Issue number6
StatePublished - Aug 11 1994

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Streptococcus pneumoniae
Anti-Bacterial Agents
Infection
Cephalosporins
Anti-Infective Agents
Cephalosporin Resistance
Therapeutics
Pneumococcal Infections
Penicillins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Management of infections caused by antibiotic-resistant Streptococcus pneumoniae. / Friedland, Ian R.; Mccracken, George H.

In: New England Journal of Medicine, Vol. 331, No. 6, 11.08.1994, p. 377-382.

Research output: Contribution to journalArticle

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