Management of Nonfunctioning Recurrent Pituitary Adenomas

Christopher J. Farrell, Tomas Garzon-Muvdi, Judd H. Fastenberg, Gurston G. Nyquist, Mindy R. Rabinowitz, Marc R. Rosen, James J. Evans

Research output: Contribution to journalReview articlepeer-review

Abstract

Pituitary adenomas are typically slow-growing benign tumors. However, 50% to 60% of tumors progress following subtotal resection and up to 30% recur after apparent complete resection. Options for treatment of recurrent pituitary adenomas include repeat surgical resection, radiation therapy, and systemic therapies. There is no consensus approach for the management of recurrent pituitary adenomas. This article reviews the natural history of recurrent adenomas and emerging biomarkers predictive of clinical behavior as well as the outcomes associated with the various treatment modalities for these challenging tumors, with an emphasis on the surgical treatment.

Original languageEnglish (US)
Pages (from-to)473-482
Number of pages10
JournalNeurosurgery clinics of North America
Volume30
Issue number4
DOIs
StatePublished - Oct 2019
Externally publishedYes

Keywords

  • KNOSP grade
  • Pituitary adenomas
  • Recurrent pituitary tumor
  • Transsphenoidal surgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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