Management of secondary hyperparathyroidism of dialysis patients

Tadao Akizawa, Motohiro Kamimura, Masahide Mizobuchi, Kazuhiro Shiizaki, Shinji Sumikado, Toshibumi Sakaguchi, Shigeo Negi, Hiroaki Ogata, Eriko Kinugasa

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Hyperphosphatemia, vitamin D deficiency, and resulted hypocalcemia have been regarded as classical pathogeneses of secondary hyperparathyroidism. These factors have been treated by the administration of phosphorus binder and vitamin D derivatives. However, these therapies have not brought about a successful result for the prevention and treatment of secondary hyperparathyroidism. The reason could be mainly attributed to the hypercalcemia that results from the administration of calcium salts as a phosphorus binder and the calcemic action of vitamin D. To prevent hypercalcemia, non-calcium containing phosphorus binder (sevelamer hydrochloride) and vitamin D analogues, which suppress PTH secretion with minimum calcemic action, have been developed. These new vitamin D analogues include 19-nor-1-alpha, 25-dihydroxyvitamin D2 (paricalcitol), 1-alpha-hydroxyvitamin D2 (doxercalciferol), 22oxa-calcitriol (maxacalcitol) and F6-calcitriol (falecalcitriol). Furthermore, calcimimetics that stimulate calcium-sensing receptor of parathyroid cells as calcium and suppress PTH secretion are now under clinical trial. Percutaneous direct injection therapy of vitamin D, vitamin D analogue or calcimimetics into parathyroid gland has also been reported. The combination of these new strategies is expected to effectively and safely suppresses secondary hyperparathyroidism that has been resistant to conventional medical treatments.

Original languageEnglish (US)
Pages (from-to)S53-S57
JournalNephrology
Volume8
Issue numberSUPPL.
DOIs
StatePublished - Oct 1 2003

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Keywords

  • Calcimimetics
  • Maxacalcitol
  • Percutaneous intervention therapy
  • Phosphorus binder
  • Secondary hyperparathyroidism
  • Vitamin D

ASJC Scopus subject areas

  • Nephrology

Cite this

Akizawa, T., Kamimura, M., Mizobuchi, M., Shiizaki, K., Sumikado, S., Sakaguchi, T., Negi, S., Ogata, H., & Kinugasa, E. (2003). Management of secondary hyperparathyroidism of dialysis patients. Nephrology, 8(SUPPL.), S53-S57. https://doi.org/10.1046/j.1440-1797.8.s.9.x