Management of sensitized pediatric patients prior to renal transplantation

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9 Scopus citations

Abstract

Background: Data on renal allograft outcome in sensitized children are scarce. We report the clinical courses of four children who received desensitization therapy prior to renal transplantation in our institution. Methods: Between 2009 and 2011, four pediatric patients with stage 5 chronic kidney disease received desensitization therapy due to: (1) positive donor-specific antibodies (DSA) and/or crossmatches with potential living donors, (2) more than three positive crossmatches with deceased donors or (3) high calculated panel-reactive antibody of >80 %. Desensitization with rituximab, intravenous immunoglobulin and bortezomib was performed in all patients. Induction therapy included combinations of plasmapheresis and/or alemtuzumab or anti-thymocyte globulin. Standard post-transplant medications included tacrolimus, mycophenolate mofetil and prednisolone. Results: Post-transplant screening revealed DSA in three patients. Biopsy showed no evidence of rejection at 1 month in two patients, one of whom developed chronic active antibody-mediated rejection 4.5 years later. One patient developed borderline acute cellular rejection at 1 month, but the serum creatinine level was stable and DSA disappeared without treatment 1 month later, with stable long-term allograft function at 3 years. Estimated or measured glomerular filtration rate of the patients ranged between 30 and 75 ml/min/1.73 m2 after 1 to 4.5 years. Conclusions: The four sensitized patients reported here who received desensitization therapy had successful renal transplants with a low risk of immediate post-transplant rejection. Overall, long-term allograft functions and complications from immunosuppression were encouraging.

Original languageEnglish (US)
Pages (from-to)1691-1698
Number of pages8
JournalPediatric Nephrology
Volume31
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • Bortezomib
  • Pediatrics
  • Plasmapheresis
  • Renal transplant
  • Rituximab
  • Sensitized

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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