TY - JOUR
T1 - Management of Stage II Germ Cell Tumors
AU - Ghandour, Rashed A.
AU - Singla, Nirmish
AU - Bagrodia, Aditya
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/8
Y1 - 2019/8
N2 - There are several treatment approaches for stage II germ cell tumors (GCTs), and a thorough understanding of the staging classification and histologic differences in tumor biology and therapeutic responsiveness is critical to determine an effective, multimodal management strategy that involves urologists, medical oncologists, and radiation oncologists. This article discusses contemporary management strategies for stage II GCTs, including chemotherapy, radiotherapy, retroperitoneal lymph node dissection (RPLND), and surveillance. Patient selection, histology, and extent of lymphadenopathy drive management, and, as both treatment and detection strategies continue to emerge and be refined, the management of patients with stage II GCT continues to evolve.
AB - There are several treatment approaches for stage II germ cell tumors (GCTs), and a thorough understanding of the staging classification and histologic differences in tumor biology and therapeutic responsiveness is critical to determine an effective, multimodal management strategy that involves urologists, medical oncologists, and radiation oncologists. This article discusses contemporary management strategies for stage II GCTs, including chemotherapy, radiotherapy, retroperitoneal lymph node dissection (RPLND), and surveillance. Patient selection, histology, and extent of lymphadenopathy drive management, and, as both treatment and detection strategies continue to emerge and be refined, the management of patients with stage II GCT continues to evolve.
KW - Chemotherapy
KW - Germ cell tumor
KW - Nonseminoma
KW - Retroperitoneal lymph node dissection
KW - Seminoma
UR - http://www.scopus.com/inward/record.url?scp=85065581411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065581411&partnerID=8YFLogxK
U2 - 10.1016/j.ucl.2019.04.002
DO - 10.1016/j.ucl.2019.04.002
M3 - Review article
C2 - 31277731
AN - SCOPUS:85065581411
SN - 0094-0143
VL - 46
SP - 363
EP - 376
JO - Urologic Clinics of North America
JF - Urologic Clinics of North America
IS - 3
ER -