Management of the critically ill patient with cirrhosis: A multidisciplinary perspective

Mitra K. Nadim; Francois Durand; John A. Kellum; Josh Levitsky; Jacqueline G. O'Leary; Constantine J. Karvellas; Jasmohan S. Bajaj; Andrew Davenport; Rajiv Jalan; Paolo Angeli; Stephen H. Caldwell; Javier Fernández; Claire Francoz; Guadalupe Garcia-Tsao; Pere Ginès; Michael G. Ison; David J. Kramer; Ravindra L. Mehta; Richard Moreau; David Mulligan; Jody C. Olson; Elizabeth A. Pomfret; Marco Senzolo; Randolph H. Steadman; Ram M. Subramanian; Jean Louis Vincent; Yuri S. Genyk

doi:10.1016/j.jhep.2015.10.019

Management of the critically ill patient with cirrhosis: A multidisciplinary perspective

Mitra K. Nadim, Francois Durand, John A. Kellum, Josh Levitsky, Jacqueline G. O'Leary, Constantine J. Karvellas, Jasmohan S. Bajaj, Andrew Davenport, Rajiv Jalan, Paolo Angeli, Stephen H. Caldwell, Javier Fernández, Claire Francoz, Guadalupe Garcia-Tsao, Pere Ginès, Michael G. Ison, David J. Kramer, Ravindra L. Mehta, Richard Moreau, David MulliganJody C. Olson, Elizabeth A. Pomfret, Marco Senzolo, Randolph H. Steadman, Ram M. Subramanian, Jean Louis Vincent, Yuri S. Genyk

Research output: Contribution to journal › Article › peer-review

221 Scopus citations

Original language	English (US)
Pages (from-to)	717-735
Number of pages	19
Journal	Journal of Hepatology
Volume	64
Issue number	3
DOIs	https://doi.org/10.1016/j.jhep.2015.10.019
State	Published - Mar 1 2016

Keywords

Acute on chronic liver failure
Cardiopulmonary dysfunction
Cirrhosis
Hematologic dysfunction
Hepatic encephalopathy
Hepatorenal syndrome
Infectious disease
Intensive care
Renal dysfunction

ASJC Scopus subject areas

Hepatology

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10.1016/j.jhep.2015.10.019

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Nadim, M. K., Durand, F., Kellum, J. A., Levitsky, J., O'Leary, J. G., Karvellas, C. J., Bajaj, J. S., Davenport, A., Jalan, R., Angeli, P., Caldwell, S. H., Fernández, J., Francoz, C., Garcia-Tsao, G., Ginès, P., Ison, M. G., Kramer, D. J., Mehta, R. L., Moreau, R., ... Genyk, Y. S. (2016). Management of the critically ill patient with cirrhosis: A multidisciplinary perspective. Journal of Hepatology, 64(3), 717-735. https://doi.org/10.1016/j.jhep.2015.10.019

Nadim, MK, Durand, F, Kellum, JA, Levitsky, J, O'Leary, JG, Karvellas, CJ, Bajaj, JS, Davenport, A, Jalan, R, Angeli, P, Caldwell, SH, Fernández, J, Francoz, C, Garcia-Tsao, G, Ginès, P, Ison, MG, Kramer, DJ, Mehta, RL, Moreau, R, Mulligan, D, Olson, JC, Pomfret, EA, Senzolo, M, Steadman, RH, Subramanian, RM, Vincent, JL & Genyk, YS 2016, 'Management of the critically ill patient with cirrhosis: A multidisciplinary perspective', Journal of Hepatology, vol. 64, no. 3, pp. 717-735. https://doi.org/10.1016/j.jhep.2015.10.019

@article{f6cde74aee124e93ad5d14fcbe6508c0,

title = "Management of the critically ill patient with cirrhosis: A multidisciplinary perspective",

keywords = "Acute on chronic liver failure, Cardiopulmonary dysfunction, Cirrhosis, Hematologic dysfunction, Hepatic encephalopathy, Hepatorenal syndrome, Infectious disease, Intensive care, Renal dysfunction",

author = "Nadim, {Mitra K.} and Francois Durand and Kellum, {John A.} and Josh Levitsky and O'Leary, {Jacqueline G.} and Karvellas, {Constantine J.} and Bajaj, {Jasmohan S.} and Andrew Davenport and Rajiv Jalan and Paolo Angeli and Caldwell, {Stephen H.} and Javier Fern{\'a}ndez and Claire Francoz and Guadalupe Garcia-Tsao and Pere Gin{\`e}s and Ison, {Michael G.} and Kramer, {David J.} and Mehta, {Ravindra L.} and Richard Moreau and David Mulligan and Olson, {Jody C.} and Pomfret, {Elizabeth A.} and Marco Senzolo and Steadman, {Randolph H.} and Subramanian, {Ram M.} and Vincent, {Jean Louis} and Genyk, {Yuri S.}",

note = "Funding Information: MKN is a consultant for Ikaria and Baxter and an Advisor and on the Data and Safety Monitoring board for La Jolla Pharmaceutical Company. FD is a consultant for Astellas, Novartis, Gilead and Bristol-Myers Squibb and has received research funding from Gilead and Astellas Pharma. JAK is a consultant for Fresenius, Baxter, Grifols, Astute Medical, Alere, AM Pharma, Spectral, Cytosorbents, Alung, Atox Bio and Bard, has received grant support from Gambro, Baxter, Bard, Astute Medical, Alere, Spectral, Grifols, Cytosorbents, Kaneka, Atox Bio and has licensing agreement with Astute Medical, Spectral and Cytosorbents. JGO is a consultant for Grifols, Gilead, Abbvie, Novartis, Astellas, Fisher Scientific and has received grant support from Grifols. PG is a consultant and on the advisory board for Ferring Pharmaceuticals and Ikaria and has research funding from Grifols and Sequana Medical. JSB is a consultant for Salix, Norgine and Grifols. RJ has received research funding from Vital Therapies, has served on Scientific Advisory Board for Conatus Pharma, received lecture fees from Gambro, has ongoing research collaboration with Gambro, Grifols, is the Principal Investigator of an Industry sponsored study (Sequana Medical), inventor for a drug, L-ornithine phenyl acetate which UCL has licensed to Ocera Therapeutics and the founder of UCL spin-out company Yaqrit ltd. and Cyberliver ltd. SHC is a consultant and has received research funding from Vital Therapies. MGI has research support from Anolinx, Chimerix, Gilead, Glaxo Smith Klein, Viro Pharma, is a consultant for Biota, Chimerix, Farmark, Genentech/Roche, Shionogi, Adamas, BioCryst, Cellex, Clarassance, Glaxo Smith Klein, GenMarkDx, Romark, Toyama/MediVector, NexBio, Theraclone, Vertex and on the Data and Safety Monitoring Board for Abbott, Jansen/Vertex. JCO is a consultant for Baxter. YSG is a consultant for Baxter. Funding Information: This conference was supported by unrestricted educational grants from Ikaria, Salix Pharmaceuticals, Gilead, Grifols, Baxter Healthcare Corporation and Astellas Pharma France. None of the companies that provided financial support for this meeting were involved in any way in the organization of the meeting, the decision regarding invited faculty, the design and contents of the meeting, the collection, management, analysis, and interpretation of the data, and preparation, review, or approval of the manuscript. None of the authors received any honorarium for their participation in this meeting. ",

year = "2016",

month = mar,

day = "1",

doi = "10.1016/j.jhep.2015.10.019",

language = "English (US)",

volume = "64",

pages = "717--735",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier",

number = "3",

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TY - JOUR

T1 - Management of the critically ill patient with cirrhosis

T2 - A multidisciplinary perspective

AU - Nadim, Mitra K.

AU - Durand, Francois

AU - Kellum, John A.

AU - Levitsky, Josh

AU - O'Leary, Jacqueline G.

AU - Karvellas, Constantine J.

AU - Bajaj, Jasmohan S.

AU - Davenport, Andrew

AU - Jalan, Rajiv

AU - Angeli, Paolo

AU - Caldwell, Stephen H.

AU - Fernández, Javier

AU - Francoz, Claire

AU - Garcia-Tsao, Guadalupe

AU - Ginès, Pere

AU - Ison, Michael G.

AU - Kramer, David J.

AU - Mehta, Ravindra L.

AU - Moreau, Richard

AU - Mulligan, David

AU - Olson, Jody C.

AU - Pomfret, Elizabeth A.

AU - Senzolo, Marco

AU - Steadman, Randolph H.

AU - Subramanian, Ram M.

AU - Vincent, Jean Louis

AU - Genyk, Yuri S.

N1 - Funding Information: MKN is a consultant for Ikaria and Baxter and an Advisor and on the Data and Safety Monitoring board for La Jolla Pharmaceutical Company. FD is a consultant for Astellas, Novartis, Gilead and Bristol-Myers Squibb and has received research funding from Gilead and Astellas Pharma. JAK is a consultant for Fresenius, Baxter, Grifols, Astute Medical, Alere, AM Pharma, Spectral, Cytosorbents, Alung, Atox Bio and Bard, has received grant support from Gambro, Baxter, Bard, Astute Medical, Alere, Spectral, Grifols, Cytosorbents, Kaneka, Atox Bio and has licensing agreement with Astute Medical, Spectral and Cytosorbents. JGO is a consultant for Grifols, Gilead, Abbvie, Novartis, Astellas, Fisher Scientific and has received grant support from Grifols. PG is a consultant and on the advisory board for Ferring Pharmaceuticals and Ikaria and has research funding from Grifols and Sequana Medical. JSB is a consultant for Salix, Norgine and Grifols. RJ has received research funding from Vital Therapies, has served on Scientific Advisory Board for Conatus Pharma, received lecture fees from Gambro, has ongoing research collaboration with Gambro, Grifols, is the Principal Investigator of an Industry sponsored study (Sequana Medical), inventor for a drug, L-ornithine phenyl acetate which UCL has licensed to Ocera Therapeutics and the founder of UCL spin-out company Yaqrit ltd. and Cyberliver ltd. SHC is a consultant and has received research funding from Vital Therapies. MGI has research support from Anolinx, Chimerix, Gilead, Glaxo Smith Klein, Viro Pharma, is a consultant for Biota, Chimerix, Farmark, Genentech/Roche, Shionogi, Adamas, BioCryst, Cellex, Clarassance, Glaxo Smith Klein, GenMarkDx, Romark, Toyama/MediVector, NexBio, Theraclone, Vertex and on the Data and Safety Monitoring Board for Abbott, Jansen/Vertex. JCO is a consultant for Baxter. YSG is a consultant for Baxter. Funding Information: This conference was supported by unrestricted educational grants from Ikaria, Salix Pharmaceuticals, Gilead, Grifols, Baxter Healthcare Corporation and Astellas Pharma France. None of the companies that provided financial support for this meeting were involved in any way in the organization of the meeting, the decision regarding invited faculty, the design and contents of the meeting, the collection, management, analysis, and interpretation of the data, and preparation, review, or approval of the manuscript. None of the authors received any honorarium for their participation in this meeting.

PY - 2016/3/1

Y1 - 2016/3/1

KW - Acute on chronic liver failure

KW - Cardiopulmonary dysfunction

KW - Cirrhosis

KW - Hematologic dysfunction

KW - Hepatic encephalopathy

KW - Hepatorenal syndrome

KW - Infectious disease

KW - Intensive care

KW - Renal dysfunction

UR - http://www.scopus.com/inward/record.url?scp=84958882811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958882811&partnerID=8YFLogxK

U2 - 10.1016/j.jhep.2015.10.019

DO - 10.1016/j.jhep.2015.10.019

M3 - Article

C2 - 26519602

AN - SCOPUS:84958882811

SN - 0168-8278

VL - 64

SP - 717

EP - 735

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 3

ER -

Management of the critically ill patient with cirrhosis: A multidisciplinary perspective

Keywords

ASJC Scopus subject areas

Access to Document

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