Management of the neck in squamous cell carcinoma of the oral cavity and oropharynx: ASCO clinical practice guideline

Shlomo A. Koyfman, Nofisat Ismaila, Doug Crook, Anil D'Cruz, Cristina P. Rodriguez, David J. Sher, Damian Silbermins, Erich M. Sturgis, Terance T. Tsue, Jared Weiss, Sue S. Yom, F. Christopher Holsinger

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

PURPOSE The aim of the current work is to provide evidence-based recommendations to practicing physicians and others on the management of the neck in patients with squamous cell carcinoma of the oral cavity and oropharynx. METHODS ASCO convened an Expert Panel of medical oncology, surgery, radiation oncology, and advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 1990 through 2018. Outcomes of interest included survival, regional disease control, neck recurrence, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations. RESULTS The literature search identified 124 relevant studies to inform the evidence base for this guideline. Six clinical scenarios were devised; three for oral cavity cancer and three for oropharynx cancer, and recommendations were generated for each one. RECOMMENDATIONS For oral cavity cancers, clinical scenarios focused on the indications for and the hallmarks of a high-quality neck dissection, indications for postoperative radiotherapy or chemoradiotherapy, and whether radiotherapy alone is sufficient elective treatment of an undissected neck compared with high-quality neck dissection. For oropharynx cancers, clinical scenarios focused on hallmarks of a high-quality neck dissection, factors that would favor operative versus nonoperative primary management, and clarifying criteria for an incomplete response to definitive chemoradiation for which salvage neck dissection would be recommended. Consensus was reached and recommendations were made for all six clinical scenarios. Additional information is available at www.asco.org/head-neck-cancer-guidelines.

Original languageEnglish (US)
Pages (from-to)1753-1774
Number of pages22
JournalJournal of Clinical Oncology
Volume37
Issue number20
DOIs
StatePublished - Jul 10 2019

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Koyfman, S. A., Ismaila, N., Crook, D., D'Cruz, A., Rodriguez, C. P., Sher, D. J., Silbermins, D., Sturgis, E. M., Tsue, T. T., Weiss, J., Yom, S. S., & Christopher Holsinger, F. (2019). Management of the neck in squamous cell carcinoma of the oral cavity and oropharynx: ASCO clinical practice guideline. Journal of Clinical Oncology, 37(20), 1753-1774. https://doi.org/10.1200/JCO.18.01921