Management of Traditional Cardiovascular Risk Factors in CKD: What Are the Data?

L. Parker Gregg, S. Susan Hedayati

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Patients with non–dialysis-dependent chronic kidney disease (NDD-CKD) are 10 times more likely to die of cardiovascular (CV) diseases than the general population, and dialysis-dependent patients are at even higher risk. Although traditional CV risk factors are highly prevalent in individuals with CKD, these patients were often excluded from studies targeting modification of these risks. Although treatment of hypertension is beneficial in CKD, the best target blood pressure has not been established. Trial data showed that renin-angiotensin-aldosterone blockade may prevent CV events in patients with CKD. The risks of aspirin may equal the benefits in NDD-CKD samples, and there are no trials testing aspirin in dialysis-dependent patients. Lipid-lowering therapy improves CV outcomes in NDD-CKD, but not in dialysis-dependent patients. Strict glycemic control prevents CV events in nonalbuminuric individuals, but showed no benefit in those with baseline albuminuria with albumin excretion > 300 mg/g, and there are no data in dialysis-dependent patients. Data for lifestyle modifications, such as weight loss, physical activity, and smoking cessation, are mostly observational and extrapolated from non-CKD samples. This comprehensive review summarizes the best existing evidence and current clinical guidelines for modification of traditional risk factors for the prevention of CV events in patients with CKD and identifies knowledge gaps.

Original languageEnglish (US)
Pages (from-to)728-744
Number of pages17
JournalAmerican Journal of Kidney Diseases
Issue number5
StatePublished - Nov 2018


  • Chronic kidney disease (CKD)
  • RAAS blockade
  • albuminuria
  • aspirin
  • cardiovascular disease (CVD)
  • cardiovascular risk
  • dialysis
  • hemodialysis (HD)
  • hyperlipidemia
  • hypertension
  • lifestyle interventions
  • modifiable risk factor
  • review
  • smoking
  • statin
  • weight loss

ASJC Scopus subject areas

  • Nephrology


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