Management of venous thromboembolism in patients with primary and metastatic brain tumors

David E. Gerber, Stuart A. Grossman, Michael B. Streiff

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Venous thromboembolism occurs commonly throughout the clinical course of patients with brain tumors. A number of hemostatic and clinical factors contribute to this hypercoagulable state. Concern over the possibility of intracranial bleeding has limited the use of anticoagulation in this population. However, mechanical approaches such as vena cava filters have high complication and treatment failure rates in patients with intracranial malignancies. In addition, the available data suggest that anticoagulation can be used safely and effectively in most of these patients. Patients with thrombocytopenia, recent neurosurgery, and tumor types prone to bleeding require special consideration. When intracranial hemorrhage does occur, it is often due to overanticoagulation, requiring prompt anticoagulation reversal and neurosurgical consultation.

Original languageEnglish (US)
Pages (from-to)1310-1318
Number of pages9
JournalJournal of Clinical Oncology
Volume24
Issue number8
DOIs
StatePublished - Mar 10 2006

Fingerprint

Venous Thromboembolism
Brain Neoplasms
Hemorrhage
Vena Cava Filters
Intracranial Hemorrhages
Neurosurgery
Hemostatics
Treatment Failure
Thrombocytopenia
Neoplasms
Referral and Consultation
Population

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Management of venous thromboembolism in patients with primary and metastatic brain tumors. / Gerber, David E.; Grossman, Stuart A.; Streiff, Michael B.

In: Journal of Clinical Oncology, Vol. 24, No. 8, 10.03.2006, p. 1310-1318.

Research output: Contribution to journalArticle

Gerber, David E. ; Grossman, Stuart A. ; Streiff, Michael B. / Management of venous thromboembolism in patients with primary and metastatic brain tumors. In: Journal of Clinical Oncology. 2006 ; Vol. 24, No. 8. pp. 1310-1318.
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