TY - JOUR
T1 - Management of venous thromboembolism in patients with primary and metastatic brain tumors
AU - Gerber, David E.
AU - Grossman, Stuart A.
AU - Streiff, Michael B.
PY - 2006/3/10
Y1 - 2006/3/10
N2 - Venous thromboembolism occurs commonly throughout the clinical course of patients with brain tumors. A number of hemostatic and clinical factors contribute to this hypercoagulable state. Concern over the possibility of intracranial bleeding has limited the use of anticoagulation in this population. However, mechanical approaches such as vena cava filters have high complication and treatment failure rates in patients with intracranial malignancies. In addition, the available data suggest that anticoagulation can be used safely and effectively in most of these patients. Patients with thrombocytopenia, recent neurosurgery, and tumor types prone to bleeding require special consideration. When intracranial hemorrhage does occur, it is often due to overanticoagulation, requiring prompt anticoagulation reversal and neurosurgical consultation.
AB - Venous thromboembolism occurs commonly throughout the clinical course of patients with brain tumors. A number of hemostatic and clinical factors contribute to this hypercoagulable state. Concern over the possibility of intracranial bleeding has limited the use of anticoagulation in this population. However, mechanical approaches such as vena cava filters have high complication and treatment failure rates in patients with intracranial malignancies. In addition, the available data suggest that anticoagulation can be used safely and effectively in most of these patients. Patients with thrombocytopenia, recent neurosurgery, and tumor types prone to bleeding require special consideration. When intracranial hemorrhage does occur, it is often due to overanticoagulation, requiring prompt anticoagulation reversal and neurosurgical consultation.
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U2 - 10.1200/JCO.2005.04.6656
DO - 10.1200/JCO.2005.04.6656
M3 - Review article
C2 - 16525187
AN - SCOPUS:33644871901
SN - 0732-183X
VL - 24
SP - 1310
EP - 1318
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 8
ER -