TY - JOUR
T1 - Management strategies for pyoderma gangrenosum
T2 - Case studies and review of literature
AU - Rozen, Shai M.
AU - Nahabedian, Maurice Y.
AU - Manson, Paul N.
PY - 2001
Y1 - 2001
N2 - Pyoderma gangrenosum (PG) is a systemic disease with cutaneous manifestations consisting of necrotizing ulceration. The etiology of PG is controversial, and optimal management strategies have not been established. Current management is primarily medical to control the systemic inflammatory process, with occasional surgical intervention at the ulcer site. Based on the current literature and on the authors' clinical experience, the optimal outcome depends on early diagnoses and a combination of medical and surgical therapy. Initial management is directed toward medical control of the inflammatory process and local wound care. Surgical strategies involve recipient site preparation via local wound care and serial allograft followed by autologous skin graft or muscle flap coverage when necessary. Long-term wound stabilization is obtained only through control of the systemic and local inflammatory process.
AB - Pyoderma gangrenosum (PG) is a systemic disease with cutaneous manifestations consisting of necrotizing ulceration. The etiology of PG is controversial, and optimal management strategies have not been established. Current management is primarily medical to control the systemic inflammatory process, with occasional surgical intervention at the ulcer site. Based on the current literature and on the authors' clinical experience, the optimal outcome depends on early diagnoses and a combination of medical and surgical therapy. Initial management is directed toward medical control of the inflammatory process and local wound care. Surgical strategies involve recipient site preparation via local wound care and serial allograft followed by autologous skin graft or muscle flap coverage when necessary. Long-term wound stabilization is obtained only through control of the systemic and local inflammatory process.
UR - http://www.scopus.com/inward/record.url?scp=0034855233&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034855233&partnerID=8YFLogxK
U2 - 10.1097/00000637-200109000-00015
DO - 10.1097/00000637-200109000-00015
M3 - Article
C2 - 11562037
AN - SCOPUS:0034855233
SN - 0148-7043
VL - 47
SP - 310
EP - 315
JO - Annals of plastic surgery
JF - Annals of plastic surgery
IS - 3
ER -