Manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate): clinical experience with a new contrast agent.

N. M. Rofsky, J. C. Weinreb

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Abstract

Despite the many imaging techniques available to evaluate the liver, deficiencies persist. The choice of the optimal method is still controversial, with competing issues of safety, efficacy, and cost. Numerous strategies to improve the results of liver imaging have been pursued, including the application of tissue-targeted contrast agents to magnetic resonance imaging (MRI). Manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (Mn-DPDP) is one of several recently developed hepatobiliary agents, targeted to functioning hepatocytes. The Mn-DPDP-enhanced MRI has demonstrated promise in the clinical trials. Contrast-to-noise measurements have shown favorable results for Mn-DPDP-enhanced MR compared to non-enhanced T1- and T2-weighted images. The ability to characterize tumors of hepatocellular origin and an improved capability for lesion detection have also been demonstrated. Furthermore, the prolonged enhancement obtained with Mn-DPDP has extended the time during which effective contrast is maintained. Importantly, no clinically significant adverse events have been demonstrated. This report will detail the clinical experience with Mn-DPDP-enhanced MRI of the abdomen.

Original languageEnglish (US)
Pages (from-to)156-168
Number of pages13
JournalMagnetic Resonance Quarterly
Volume8
Issue number3
StatePublished - Sep 1992

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Manganese
Contrast Media
Phosphates
Magnetic Resonance Imaging
Liver
Abdomen
Noise
Hepatocytes
N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid
Clinical Trials
Safety
Costs and Cost Analysis
Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate): clinical experience with a new contrast agent.",
abstract = "Despite the many imaging techniques available to evaluate the liver, deficiencies persist. The choice of the optimal method is still controversial, with competing issues of safety, efficacy, and cost. Numerous strategies to improve the results of liver imaging have been pursued, including the application of tissue-targeted contrast agents to magnetic resonance imaging (MRI). Manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (Mn-DPDP) is one of several recently developed hepatobiliary agents, targeted to functioning hepatocytes. The Mn-DPDP-enhanced MRI has demonstrated promise in the clinical trials. Contrast-to-noise measurements have shown favorable results for Mn-DPDP-enhanced MR compared to non-enhanced T1- and T2-weighted images. The ability to characterize tumors of hepatocellular origin and an improved capability for lesion detection have also been demonstrated. Furthermore, the prolonged enhancement obtained with Mn-DPDP has extended the time during which effective contrast is maintained. Importantly, no clinically significant adverse events have been demonstrated. This report will detail the clinical experience with Mn-DPDP-enhanced MRI of the abdomen.",
author = "Rofsky, {N. M.} and Weinreb, {J. C.}",
year = "1992",
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