Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI

Sara Chirayil, Veronica Clavijo Jordan, André F. Martins, Namini Paranawithana, S. James Ratnakar, A. Dean Sherry

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A Mn(II)-based zinc-sensitive MRI contrast agent, MnPyC3A-BPEN, was prepared, characterized, and applied in imaging experiments to detect glucose-stimulated zinc secretion (GSZS) from the mouse pancreas and prostate in vivo. Thermodynamic and kinetic stability tests showed that MnPyC3A-BPEN has superior kinetic inertness compared to GdDTPA, is less susceptible to transmetalation in the presence of excess Zn2+ ions, and less susceptible to transchelation by albumin. In comparison with other gadolinium-based zinc sensors bearing a single zinc binding moiety, MnPyC3A-BPEN appears to be a reliable alternative for imaging β-cell function in the pancreas and glucose-stimulated zinc secretion from the prostate.

Original languageEnglish (US)
Pages (from-to)2168-2177
Number of pages10
JournalInorganic Chemistry
Volume60
Issue number4
DOIs
StatePublished - Feb 15 2021

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

Fingerprint

Dive into the research topics of 'Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI'. Together they form a unique fingerprint.

Cite this