Manipulation of host membranes by bacterial effectors

Hyeilin Ham, Anju Sreelatha, Kim Orth

Research output: Contribution to journalReview article

86 Scopus citations

Abstract

Bacterial pathogens interact with host membranes to trigger a wide range of cellular processes during the course of infection. These processes include alterations to the dynamics between the plasma membrane and the actin cytoskeleton, and subversion of the membrane-associated pathways involved in vesicle trafficking. Such changes facilitate the entry and replication of the pathogen, and prevent its phagocytosis and degradation. In this Review, we describe the manipulation of host membranes by numerous bacterial effectors that target phosphoinositide metabolism, GTPase signalling and autophagy.

Original languageEnglish (US)
Pages (from-to)635-646
Number of pages12
JournalNature Reviews Microbiology
Volume9
Issue number9
DOIs
StatePublished - Sep 1 2011

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ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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