Manipulation of novel nano-prodrug composed of organic pigment-based hybrid network and its optical uses

Zhan Zhou, Yuhui Zheng, Chengcheng Zhang, Jiajia Wen, Qianming Wang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Here we developed the first case of pyropheophorbide-a-loaded PEGylated-hybrid carbon nanohorns (CNH-Pyro) to study tumor targeting therapy. During incubation with living cells, CNH-Pyro exhibited very intense red emissions. The intracellular imaging results were carried out by flow cytometry based on four different kinds of cell lines (including three adherent cell lines and one suspension cell line). Compared with free pyropheophorbide-a, CNH-Pyro demonstrated enhanced photodynamic tumor ablation efficiency during in vitro experiments due to improved biocompatibility of the hybrid nanomaterial and the photothermal therapy effect derived from carbon-network structure. Trypan blue staining experiments supported that the cell fate was dependent on the synergistic effects of both CNH-Pyro and laser irradiations. These results indicated that the chlorin-entrapped carbon nanohorns could provide powerful delivery vehicles for increasing photodynamic efficacy and possess early identification of the disease.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalMaterials Science and Engineering C
Volume70
DOIs
StatePublished - Jan 1 2017

Keywords

  • Hybrid material
  • Photodynamic therapy
  • Photosensitizer

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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