Mannose-resistant hemagglutination and P receptor recognition of uropathogenic Escherichia coli isolated from adult patients

R. M. Gander, V. L. Thomas, M. Forland

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Abstract

Adhesins of 211 strains of uropathogenic Escherichia coli and 19 strains of normal fecal E. coli were characterized by patterns of agglutination with human erythrocytes, Saccharomyces cerevisiae, and horse erythrocytes coated with the P blood-group receptor (P). Mannose-resistant (MR) hemagglutination was significantly associated with P agglutination (P < .001). E. coli expressing MR and/or P (MR/P) agglutinins concurrently with mannose-sensitive (MS) agglutinins predominated in all clinical categories. The highest percentage of E. coli demonstrating MR/P agglutinins, in the absence of MS agglutinins, was recovered from patients with acute pyelonephritis (35%) compared with percentages of patients with chronic pyelonephritis (13%), asymptomatic bacteriuria (16%), cystitis (11%), and normal fecal control E. coli (11%). Sixty-nine percent of E. coli isolates causing acute pyelonephritis agglutinated P-coated horse erythrocytes compared with only 11% of the fecal isolates. Strains expressing MR/P agglutinins (in the absence of MS agglutinins) isolated from patients with acute pyelonephritis, chronic pyelonephritis, and asymptomatic bacteriuria were significantly associated with the presence of antibody-coated bacteria in patients' urine sediments (P < .010), an observation indicative of an immune response associated with bacterial invasion of host tissues.

Original languageEnglish (US)
Pages (from-to)508-513
Number of pages6
JournalJournal of Infectious Diseases
Volume151
Issue number3
StatePublished - 1985

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Uropathogenic Escherichia coli
Hemagglutination
Mannose
Agglutinins
Pyelonephritis
Escherichia coli
Bacteriuria
Erythrocytes
Agglutination
Horses
Cystitis
Blood Group Antigens
Saccharomyces cerevisiae
Observation
Urine
Bacteria
Antibodies

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Mannose-resistant hemagglutination and P receptor recognition of uropathogenic Escherichia coli isolated from adult patients. / Gander, R. M.; Thomas, V. L.; Forland, M.

In: Journal of Infectious Diseases, Vol. 151, No. 3, 1985, p. 508-513.

Research output: Contribution to journalArticle

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