Mapping of the pulmonary surfactant SP5 (SFTP2) Locus to 8p21 and characterization of a microsatellite repeat marker that shows frequent loss of heterozygosity in human carcinomas

Stephen Wood, M. Lisa Yaremko, Michael Schertzer, Pond R. Kelemen, John Minna, Carol A. Westbrook

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We have identified 4 cosmids at the SFTP2 locus by cDNA hybridization. SFTP2 was mapped using a polymorphic CA repeat and localized to 8p21 by FISH. Allele loss in carcinomas was detected using this PCR marker. Among 11 lung and colon tumors, 6 of 9 informative cases exhibited allelic loss.

Original languageEnglish (US)
Pages (from-to)597-600
Number of pages4
JournalGenomics
Volume24
Issue number3
DOIs
StatePublished - Dec 1994

ASJC Scopus subject areas

  • Genetics

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