Mapping of the Pulmonary Surfactant SP5 (SFTP2) Locus to 8p21 and Characterization of a Microsatellite Repeat Marker That Shows Frequent Loss of Heterozygosity in Human Carcinomas

Stephen Wood, M. Lisa Yaremko, Michael Schertzer, Pond R. Kelemen, John Minna, Carol A. Westbrook

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We have identified 4 cosmids at the SFTP2 locus by cDNA hybridization. SFTP2 was mapped using a polymorphic CA repeat and localized to 8p21 by FISH. Allele loss in carcinomas was detected using this PCR marker. Among 11 lung and colon tumors, 6 of 9 informative cases exhibited allelic loss.

Original languageEnglish (US)
Pages (from-to)597-600
Number of pages4
JournalGenomics
Volume24
Issue number3
DOIs
StatePublished - Dec 1994

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Pulmonary Surfactants
Cosmids
Loss of Heterozygosity
Microsatellite Repeats
Colon
Complementary DNA
Alleles
Carcinoma
Polymerase Chain Reaction
Lung
Neoplasms

ASJC Scopus subject areas

  • Genetics

Cite this

Mapping of the Pulmonary Surfactant SP5 (SFTP2) Locus to 8p21 and Characterization of a Microsatellite Repeat Marker That Shows Frequent Loss of Heterozygosity in Human Carcinomas. / Wood, Stephen; Yaremko, M. Lisa; Schertzer, Michael; Kelemen, Pond R.; Minna, John; Westbrook, Carol A.

In: Genomics, Vol. 24, No. 3, 12.1994, p. 597-600.

Research output: Contribution to journalArticle

Wood, Stephen ; Yaremko, M. Lisa ; Schertzer, Michael ; Kelemen, Pond R. ; Minna, John ; Westbrook, Carol A. / Mapping of the Pulmonary Surfactant SP5 (SFTP2) Locus to 8p21 and Characterization of a Microsatellite Repeat Marker That Shows Frequent Loss of Heterozygosity in Human Carcinomas. In: Genomics. 1994 ; Vol. 24, No. 3. pp. 597-600.
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