Mapping residual transmission for malaria elimination

Robert C. Reiner, Arnaud Le Menach, Simon Kunene, Nyasatu Ntshalintshali, Michelle S. Hsiang, T. Alex Perkins, Bryan Greenhouse, Andrew J. Tatem, Justin M. Cohen, David L. Smith

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Eliminating malaria from a defined region involves draining the endemic parasite reservoir and minimizing local malaria transmission around imported malaria infections. In the last phases of malaria elimination, as universal interventions reap diminishing marginal returns, national resources must become increasingly devoted to identifying where residual transmission is occurring. The needs for accurate measures of progress and practical advice about how to allocate scarce resources require new analytical methods to quantify fine-grained heterogeneity in malaria risk. Using routine national surveillance data from Swaziland (a sub-Saharan country on the verge of elimination), we estimated individual reproductive numbers. Fine-grained maps of reproductive numbers and local malaria importation rates were combined to show ‘malariogenic potential’, a first for malaria elimination. As countries approach elimination, these individual-based measures of transmission risk provide meaningful metrics for planning programmatic responses and prioritizing areas where interventions will contribute most to malaria elimination.

Original languageEnglish (US)
Article numbere9520
JournaleLife
Volume4
Issue numberDECEMBER2015
DOIs
StatePublished - Dec 29 2015

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Malaria
Planning
Swaziland
Parasites
Infection

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Reiner, R. C., Le Menach, A., Kunene, S., Ntshalintshali, N., Hsiang, M. S., Perkins, T. A., ... Smith, D. L. (2015). Mapping residual transmission for malaria elimination. eLife, 4(DECEMBER2015), [e9520]. https://doi.org/10.7554/eLife.09520

Mapping residual transmission for malaria elimination. / Reiner, Robert C.; Le Menach, Arnaud; Kunene, Simon; Ntshalintshali, Nyasatu; Hsiang, Michelle S.; Perkins, T. Alex; Greenhouse, Bryan; Tatem, Andrew J.; Cohen, Justin M.; Smith, David L.

In: eLife, Vol. 4, No. DECEMBER2015, e9520, 29.12.2015.

Research output: Contribution to journalArticle

Reiner, RC, Le Menach, A, Kunene, S, Ntshalintshali, N, Hsiang, MS, Perkins, TA, Greenhouse, B, Tatem, AJ, Cohen, JM & Smith, DL 2015, 'Mapping residual transmission for malaria elimination', eLife, vol. 4, no. DECEMBER2015, e9520. https://doi.org/10.7554/eLife.09520
Reiner RC, Le Menach A, Kunene S, Ntshalintshali N, Hsiang MS, Perkins TA et al. Mapping residual transmission for malaria elimination. eLife. 2015 Dec 29;4(DECEMBER2015). e9520. https://doi.org/10.7554/eLife.09520
Reiner, Robert C. ; Le Menach, Arnaud ; Kunene, Simon ; Ntshalintshali, Nyasatu ; Hsiang, Michelle S. ; Perkins, T. Alex ; Greenhouse, Bryan ; Tatem, Andrew J. ; Cohen, Justin M. ; Smith, David L. / Mapping residual transmission for malaria elimination. In: eLife. 2015 ; Vol. 4, No. DECEMBER2015.
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