Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

Kazuhiko Yamada, Koji Yazawa, Akira Shimizu, Takehiro Iwanaga, Yosuke Hisashi, Matthew Nuhn, Patricia O'Malley, Shuji Nobori, Parsia A. Vagefi, Clive Patience, Jay Fishman, David K.C. Cooper, Robert J. Hawley, Julia Greenstein, Henk Jan Schuurman, Michel Awwad, Megan Sykes, David H. Sachs

Research output: Contribution to journalArticle

452 Citations (Scopus)

Abstract

The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using α-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.

Original languageEnglish (US)
Pages (from-to)32-34
Number of pages3
JournalNature Medicine
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

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Galactosyltransferases
Gene Knockout Techniques
Papio
Heterografts
Swine
Genes
Tissue
Animal Structures
Kidney
Organ Transplantation
Creatinine
Animals

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. / Yamada, Kazuhiko; Yazawa, Koji; Shimizu, Akira; Iwanaga, Takehiro; Hisashi, Yosuke; Nuhn, Matthew; O'Malley, Patricia; Nobori, Shuji; Vagefi, Parsia A.; Patience, Clive; Fishman, Jay; Cooper, David K.C.; Hawley, Robert J.; Greenstein, Julia; Schuurman, Henk Jan; Awwad, Michel; Sykes, Megan; Sachs, David H.

In: Nature Medicine, Vol. 11, No. 1, 01.01.2005, p. 32-34.

Research output: Contribution to journalArticle

Yamada, K, Yazawa, K, Shimizu, A, Iwanaga, T, Hisashi, Y, Nuhn, M, O'Malley, P, Nobori, S, Vagefi, PA, Patience, C, Fishman, J, Cooper, DKC, Hawley, RJ, Greenstein, J, Schuurman, HJ, Awwad, M, Sykes, M & Sachs, DH 2005, 'Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue', Nature Medicine, vol. 11, no. 1, pp. 32-34. https://doi.org/10.1038/nm1172
Yamada, Kazuhiko ; Yazawa, Koji ; Shimizu, Akira ; Iwanaga, Takehiro ; Hisashi, Yosuke ; Nuhn, Matthew ; O'Malley, Patricia ; Nobori, Shuji ; Vagefi, Parsia A. ; Patience, Clive ; Fishman, Jay ; Cooper, David K.C. ; Hawley, Robert J. ; Greenstein, Julia ; Schuurman, Henk Jan ; Awwad, Michel ; Sykes, Megan ; Sachs, David H. / Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. In: Nature Medicine. 2005 ; Vol. 11, No. 1. pp. 32-34.
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