Marked thrombosis and calcification of porcine heterograft valves

M. R. Platt, L. J. Mills, A. S. Estrera, L. D. Hillis, L. M. Buja, J. T. Willerson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Prosthetic valvular dysfunction resulting in clinically significant complications occurred in six patients with Hancock porcine heterografts. In one patient with a prosthetic valve in the aortic position, massive prosthetic thrombosis resulted in sudden death. In two patients who had a mitral prosthesis, thrombosis resulted in congestive heart failure and systemic embolization; in one of the latter patients, the thrombi were infected with Candida sp. Calcification of organizing thrombi and cusp tissue resulted in valvular stenosis and congestive heart failure in one patient with an aortic prosthesis and in two patients with mitral prostheses. Four of the six patients died. The prosthetic valves had been in place for 6 months to 3 years before onset of complications. During the same 4-year interval, over 400 porcine prostheses were inserted. This report provides further clarification of the nature and frequency of clinical complications related to degeneration and thrombosis of Hancock porcine heterograft valves.

Original languageEnglish (US)
Pages (from-to)862-869
Number of pages8
JournalCirculation
Volume62
Issue number4
StatePublished - 1980

Fingerprint

Heterografts
Thrombosis
Swine
Prostheses and Implants
Heart Failure
Sudden Death
Aortic Valve
Candida
Pathologic Constriction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Platt, M. R., Mills, L. J., Estrera, A. S., Hillis, L. D., Buja, L. M., & Willerson, J. T. (1980). Marked thrombosis and calcification of porcine heterograft valves. Circulation, 62(4), 862-869.

Marked thrombosis and calcification of porcine heterograft valves. / Platt, M. R.; Mills, L. J.; Estrera, A. S.; Hillis, L. D.; Buja, L. M.; Willerson, J. T.

In: Circulation, Vol. 62, No. 4, 1980, p. 862-869.

Research output: Contribution to journalArticle

Platt, MR, Mills, LJ, Estrera, AS, Hillis, LD, Buja, LM & Willerson, JT 1980, 'Marked thrombosis and calcification of porcine heterograft valves', Circulation, vol. 62, no. 4, pp. 862-869.
Platt MR, Mills LJ, Estrera AS, Hillis LD, Buja LM, Willerson JT. Marked thrombosis and calcification of porcine heterograft valves. Circulation. 1980;62(4):862-869.
Platt, M. R. ; Mills, L. J. ; Estrera, A. S. ; Hillis, L. D. ; Buja, L. M. ; Willerson, J. T. / Marked thrombosis and calcification of porcine heterograft valves. In: Circulation. 1980 ; Vol. 62, No. 4. pp. 862-869.
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