Markedly Increased Mesiotemporal Lobe Metabolism in a Case with PLEDs: Further Evidence that PLEDs are a Manifestation of Partial Status Epilepticus

Adrian Handforth, Jung Tung Cheng, Mark A. Mandelkern, David M. Treiman

Research output: Contribution to journalArticlepeer-review

122 Scopus citations

Abstract

Summary: The pathophysiologic and clinical significance of periodic lateralized epileptiform discharges (PLEDs) is unclear; whether PLEDs represent an ictal condition that should be treated remains uncertain. We performed FDG‐positron emission computed tomography (FDG‐ET) in a patient with PLEDs at 3 days, 18 days, and 10 weeks after onset. During left temporal PLEds, the initial scan showed intense hypermetabolism of the left mesiotemporal region. The second scan, performed when PLEDs were resolving, displayed reduced hypermetabolism. The follow‐up scan, when PLEDs had resolved, showed left temporal hypometabolism. These findings, together with clinical evidence from the literature, are compatible with the interpretation that PLEDs represent partial status epilepticus (SE); whether vigorous therapy is required to prevent neuronal damage from this focal seizure activity remains uncertain.

Original languageEnglish (US)
Pages (from-to)876-881
Number of pages6
JournalEpilepsia
Volume35
Issue number4
DOIs
StatePublished - Jul 1994

Keywords

  • Electroencephalography
  • Partial seizures
  • Positron emission tomography
  • Status epilepticus
  • Temporal lobe

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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