MARs of antigen receptor and co-receptor genes

Richard H. Scheuermann, William T. Garrard

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

MARs are cis-acting DNA sequences that function both negatively and positively in conjunction with transcriptional enhancers to regulate antigen receptor and co-receptor genes. Evidence exists that certain tissue-specific nuclear proteins are involved in this regulation, including SATB1, Bright, and Cux/CDP, possibly by modulating intranuclear gene location, histone acetylation, DNA methylation, and/or nucleosome positioning.

Original languageEnglish (US)
Pages (from-to)295-310
Number of pages16
JournalCritical Reviews in Eukaryotic Gene Expression
Volume9
Issue number3-4
DOIs
StatePublished - Jan 1 1999

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Keywords

  • Chromatin remodeling
  • DNA methylation
  • Gene rearrangement
  • Histone acetylation
  • Immunoglobulin and T-cell receptor genes
  • Nuclear matrix
  • SAR
  • Somatic hypermutation
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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