MARs of antigen receptor and co-receptor genes

Richard H. Scheuermann; William T. Garrard

doi:10.1615/CritRevEukarGeneExpr.v9.i3-4.140

MARs of antigen receptor and co-receptor genes

Richard H. Scheuermann, William T. Garrard

Molecular Biology

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

MARs are cis-acting DNA sequences that function both negatively and positively in conjunction with transcriptional enhancers to regulate antigen receptor and co-receptor genes. Evidence exists that certain tissue-specific nuclear proteins are involved in this regulation, including SATB1, Bright, and Cux/CDP, possibly by modulating intranuclear gene location, histone acetylation, DNA methylation, and/or nucleosome positioning.

Original language	English (US)
Pages (from-to)	295-310
Number of pages	16
Journal	Critical Reviews in Eukaryotic Gene Expression
Volume	9
Issue number	3-4
DOIs	https://doi.org/10.1615/CritRevEukarGeneExpr.v9.i3-4.140
State	Published - 1999

Keywords

Chromatin remodeling
DNA methylation
Gene rearrangement
Histone acetylation
Immunoglobulin and T-cell receptor genes
Nuclear matrix
SAR
Somatic hypermutation
Transcription

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.1615/CritRevEukarGeneExpr.v9.i3-4.140

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abstract = "MARs are cis-acting DNA sequences that function both negatively and positively in conjunction with transcriptional enhancers to regulate antigen receptor and co-receptor genes. Evidence exists that certain tissue-specific nuclear proteins are involved in this regulation, including SATB1, Bright, and Cux/CDP, possibly by modulating intranuclear gene location, histone acetylation, DNA methylation, and/or nucleosome positioning.",

keywords = "Chromatin remodeling, DNA methylation, Gene rearrangement, Histone acetylation, Immunoglobulin and T-cell receptor genes, Nuclear matrix, SAR, Somatic hypermutation, Transcription",

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AU - Garrard, William T.

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AB - MARs are cis-acting DNA sequences that function both negatively and positively in conjunction with transcriptional enhancers to regulate antigen receptor and co-receptor genes. Evidence exists that certain tissue-specific nuclear proteins are involved in this regulation, including SATB1, Bright, and Cux/CDP, possibly by modulating intranuclear gene location, histone acetylation, DNA methylation, and/or nucleosome positioning.

KW - Chromatin remodeling

KW - DNA methylation

KW - Gene rearrangement

KW - Histone acetylation

KW - Immunoglobulin and T-cell receptor genes

KW - Nuclear matrix

KW - SAR

KW - Somatic hypermutation

KW - Transcription

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DO - 10.1615/CritRevEukarGeneExpr.v9.i3-4.140

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ER -

MARs of antigen receptor and co-receptor genes

Abstract

Keywords

ASJC Scopus subject areas

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