MARs of antigen receptor and co-receptor genes

Richard H. Scheuermann, William T. Garrard

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

MARs are cis-acting DNA sequences that function both negatively and positively in conjunction with transcriptional enhancers to regulate antigen receptor and co-receptor genes. Evidence exists that certain tissue-specific nuclear proteins are involved in this regulation, including SATB1, Bright, and Cux/CDP, possibly by modulating intranuclear gene location, histone acetylation, DNA methylation, and/or nucleosome positioning.

Original languageEnglish (US)
Pages (from-to)295-310
Number of pages16
JournalCritical Reviews in Eukaryotic Gene Expression
Volume9
Issue number3-4
StatePublished - 1999

Fingerprint

Antigen Receptors
Cytidine Diphosphate
Nucleosomes
DNA Methylation
Acetylation
Nuclear Proteins
Histones
Genes

Keywords

  • Chromatin remodeling
  • DNA methylation
  • Gene rearrangement
  • Histone acetylation
  • Immunoglobulin and T-cell receptor genes
  • Nuclear matrix
  • SAR
  • Somatic hypermutation
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Scheuermann, R. H., & Garrard, W. T. (1999). MARs of antigen receptor and co-receptor genes. Critical Reviews in Eukaryotic Gene Expression, 9(3-4), 295-310.

MARs of antigen receptor and co-receptor genes. / Scheuermann, Richard H.; Garrard, William T.

In: Critical Reviews in Eukaryotic Gene Expression, Vol. 9, No. 3-4, 1999, p. 295-310.

Research output: Contribution to journalArticle

Scheuermann, RH & Garrard, WT 1999, 'MARs of antigen receptor and co-receptor genes', Critical Reviews in Eukaryotic Gene Expression, vol. 9, no. 3-4, pp. 295-310.
Scheuermann, Richard H. ; Garrard, William T. / MARs of antigen receptor and co-receptor genes. In: Critical Reviews in Eukaryotic Gene Expression. 1999 ; Vol. 9, No. 3-4. pp. 295-310.
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