Mass drug administration for the control and elimination of Plasmodium vivax malaria: An ecological study from Jiangsu province, China

Michelle S. Hsiang, Jimee Hwang, Amy R. Tao, Yaobao Liu, Adam Bennett, George Dennis Shanks, Jun Cao, Stephen Patrick Kachur, Richard G A Feachem, Roly D. Gosling, Qi Gao

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Abstract

Background: Recent progress in malaria control has caused renewed interest in mass drug administration (MDA) as a potential elimination strategy but the evidence base is limited. China has extensive experience with MDA, but it is not well documented. Methods. An ecological study was conducted to describe the use of MDA for the control and elimination of Plasmodium vivax in Jiangsu Province and explore the association between MDA and malaria incidence. Two periods were focused on: 1973 to 1983 when malaria burden was high and MDA administered to highly endemic counties province-wide, and 2000 to 2009, when malaria burden was low and a focal approach was used in two counties. All available data about the strategies implemented, MDA coverage, co-interventions, incidence, and adverse events were collected and described. Joinpoint analysis was used to describe trends in incidence and the relationship between MDA coverage and incidence was explored in negative binomial regression models. Results: From 1973 to 1983, MDA with pyrimethamine and primaquine was used on a large scale, with up to 30 million people in target counties covered in a peak year (50% of the total population). Joinpoint analyses identified declines in annual incidence,-56.7% (95% CI-75.5 to-23.7%) from 1973-1976 and-12.4% (95% CI-24.7 to 2.0%) from 1976-1983. Population average negative binomial models identified a relationship between higher total population MDA coverage and lower monthly incidence from 1973-1976, IRR 0.98 (95% CI 0.97 to 1.00), while co-interventions, rainfall and GDP were not associated. From 2000-2009, incidence in two counties declined (annual change-43.7 to-14.0%) during a time when focal MDA using chloroquine and primaquine was targeted to villages and/or individuals residing near passively detected index cases (median 0.04% of total population). Although safety data were not collected systematically, there were rare reports of serious but non-fatal events. Conclusions: In Jiangsu Province, China, large-scale MDA was implemented and associated with declines in high P. vivax malaria transmission; a more recent focal approach may have contributed to interruption of transmission. MDA should be considered a potential key strategy for malaria control and elimination.

Original languageEnglish (US)
Article number383
JournalMalaria Journal
Volume12
Issue number1
DOIs
StatePublished - 2013

Fingerprint

Vivax Malaria
Drug and Narcotic Control
China
Pharmaceutical Preparations
Malaria
Incidence
Primaquine
Statistical Models
Population
Plasmodium vivax
Pyrimethamine
Chloroquine

Keywords

  • China
  • Malaria elimination
  • Mass drug administration
  • Plasmodium vivax
  • Primaquine

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Mass drug administration for the control and elimination of Plasmodium vivax malaria : An ecological study from Jiangsu province, China. / Hsiang, Michelle S.; Hwang, Jimee; Tao, Amy R.; Liu, Yaobao; Bennett, Adam; Shanks, George Dennis; Cao, Jun; Kachur, Stephen Patrick; Feachem, Richard G A; Gosling, Roly D.; Gao, Qi.

In: Malaria Journal, Vol. 12, No. 1, 383, 2013.

Research output: Contribution to journalArticle

Hsiang, MS, Hwang, J, Tao, AR, Liu, Y, Bennett, A, Shanks, GD, Cao, J, Kachur, SP, Feachem, RGA, Gosling, RD & Gao, Q 2013, 'Mass drug administration for the control and elimination of Plasmodium vivax malaria: An ecological study from Jiangsu province, China', Malaria Journal, vol. 12, no. 1, 383. https://doi.org/10.1186/1475-2875-12-383
Hsiang, Michelle S. ; Hwang, Jimee ; Tao, Amy R. ; Liu, Yaobao ; Bennett, Adam ; Shanks, George Dennis ; Cao, Jun ; Kachur, Stephen Patrick ; Feachem, Richard G A ; Gosling, Roly D. ; Gao, Qi. / Mass drug administration for the control and elimination of Plasmodium vivax malaria : An ecological study from Jiangsu province, China. In: Malaria Journal. 2013 ; Vol. 12, No. 1.
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abstract = "Background: Recent progress in malaria control has caused renewed interest in mass drug administration (MDA) as a potential elimination strategy but the evidence base is limited. China has extensive experience with MDA, but it is not well documented. Methods. An ecological study was conducted to describe the use of MDA for the control and elimination of Plasmodium vivax in Jiangsu Province and explore the association between MDA and malaria incidence. Two periods were focused on: 1973 to 1983 when malaria burden was high and MDA administered to highly endemic counties province-wide, and 2000 to 2009, when malaria burden was low and a focal approach was used in two counties. All available data about the strategies implemented, MDA coverage, co-interventions, incidence, and adverse events were collected and described. Joinpoint analysis was used to describe trends in incidence and the relationship between MDA coverage and incidence was explored in negative binomial regression models. Results: From 1973 to 1983, MDA with pyrimethamine and primaquine was used on a large scale, with up to 30 million people in target counties covered in a peak year (50{\%} of the total population). Joinpoint analyses identified declines in annual incidence,-56.7{\%} (95{\%} CI-75.5 to-23.7{\%}) from 1973-1976 and-12.4{\%} (95{\%} CI-24.7 to 2.0{\%}) from 1976-1983. Population average negative binomial models identified a relationship between higher total population MDA coverage and lower monthly incidence from 1973-1976, IRR 0.98 (95{\%} CI 0.97 to 1.00), while co-interventions, rainfall and GDP were not associated. From 2000-2009, incidence in two counties declined (annual change-43.7 to-14.0{\%}) during a time when focal MDA using chloroquine and primaquine was targeted to villages and/or individuals residing near passively detected index cases (median 0.04{\%} of total population). Although safety data were not collected systematically, there were rare reports of serious but non-fatal events. Conclusions: In Jiangsu Province, China, large-scale MDA was implemented and associated with declines in high P. vivax malaria transmission; a more recent focal approach may have contributed to interruption of transmission. MDA should be considered a potential key strategy for malaria control and elimination.",
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T2 - An ecological study from Jiangsu province, China

AU - Hsiang, Michelle S.

AU - Hwang, Jimee

AU - Tao, Amy R.

AU - Liu, Yaobao

AU - Bennett, Adam

AU - Shanks, George Dennis

AU - Cao, Jun

AU - Kachur, Stephen Patrick

AU - Feachem, Richard G A

AU - Gosling, Roly D.

AU - Gao, Qi

PY - 2013

Y1 - 2013

N2 - Background: Recent progress in malaria control has caused renewed interest in mass drug administration (MDA) as a potential elimination strategy but the evidence base is limited. China has extensive experience with MDA, but it is not well documented. Methods. An ecological study was conducted to describe the use of MDA for the control and elimination of Plasmodium vivax in Jiangsu Province and explore the association between MDA and malaria incidence. Two periods were focused on: 1973 to 1983 when malaria burden was high and MDA administered to highly endemic counties province-wide, and 2000 to 2009, when malaria burden was low and a focal approach was used in two counties. All available data about the strategies implemented, MDA coverage, co-interventions, incidence, and adverse events were collected and described. Joinpoint analysis was used to describe trends in incidence and the relationship between MDA coverage and incidence was explored in negative binomial regression models. Results: From 1973 to 1983, MDA with pyrimethamine and primaquine was used on a large scale, with up to 30 million people in target counties covered in a peak year (50% of the total population). Joinpoint analyses identified declines in annual incidence,-56.7% (95% CI-75.5 to-23.7%) from 1973-1976 and-12.4% (95% CI-24.7 to 2.0%) from 1976-1983. Population average negative binomial models identified a relationship between higher total population MDA coverage and lower monthly incidence from 1973-1976, IRR 0.98 (95% CI 0.97 to 1.00), while co-interventions, rainfall and GDP were not associated. From 2000-2009, incidence in two counties declined (annual change-43.7 to-14.0%) during a time when focal MDA using chloroquine and primaquine was targeted to villages and/or individuals residing near passively detected index cases (median 0.04% of total population). Although safety data were not collected systematically, there were rare reports of serious but non-fatal events. Conclusions: In Jiangsu Province, China, large-scale MDA was implemented and associated with declines in high P. vivax malaria transmission; a more recent focal approach may have contributed to interruption of transmission. MDA should be considered a potential key strategy for malaria control and elimination.

AB - Background: Recent progress in malaria control has caused renewed interest in mass drug administration (MDA) as a potential elimination strategy but the evidence base is limited. China has extensive experience with MDA, but it is not well documented. Methods. An ecological study was conducted to describe the use of MDA for the control and elimination of Plasmodium vivax in Jiangsu Province and explore the association between MDA and malaria incidence. Two periods were focused on: 1973 to 1983 when malaria burden was high and MDA administered to highly endemic counties province-wide, and 2000 to 2009, when malaria burden was low and a focal approach was used in two counties. All available data about the strategies implemented, MDA coverage, co-interventions, incidence, and adverse events were collected and described. Joinpoint analysis was used to describe trends in incidence and the relationship between MDA coverage and incidence was explored in negative binomial regression models. Results: From 1973 to 1983, MDA with pyrimethamine and primaquine was used on a large scale, with up to 30 million people in target counties covered in a peak year (50% of the total population). Joinpoint analyses identified declines in annual incidence,-56.7% (95% CI-75.5 to-23.7%) from 1973-1976 and-12.4% (95% CI-24.7 to 2.0%) from 1976-1983. Population average negative binomial models identified a relationship between higher total population MDA coverage and lower monthly incidence from 1973-1976, IRR 0.98 (95% CI 0.97 to 1.00), while co-interventions, rainfall and GDP were not associated. From 2000-2009, incidence in two counties declined (annual change-43.7 to-14.0%) during a time when focal MDA using chloroquine and primaquine was targeted to villages and/or individuals residing near passively detected index cases (median 0.04% of total population). Although safety data were not collected systematically, there were rare reports of serious but non-fatal events. Conclusions: In Jiangsu Province, China, large-scale MDA was implemented and associated with declines in high P. vivax malaria transmission; a more recent focal approach may have contributed to interruption of transmission. MDA should be considered a potential key strategy for malaria control and elimination.

KW - China

KW - Malaria elimination

KW - Mass drug administration

KW - Plasmodium vivax

KW - Primaquine

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