Maternal BMI, glucose tolerance, and adverse pregnancy outcomes

Alison M. Stuebe, Mark B. Landon, Yinglei Lai, Catherine Y. Spong, Marshall W. Carpenter, Susan M. Ramin, Brian Casey, Ronald J. Wapner, Michael W. Varner, Dwight J. Rouse, Anthony Sciscione, Patrick Catalano, Margaret Harper, George Saade, Yoram Sorokin, Alan M. Peaceman, Jorge E. Tolosa

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome. STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity. RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass. CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.

Original languageEnglish (US)
Pages (from-to)62.e1-62.e7
JournalAmerican journal of obstetrics and gynecology
Volume207
Issue number1
DOIs
StatePublished - Jul 2012

Keywords

  • body mass index
  • gestational diabetes mellitus (GDM)
  • glycemia
  • obesity

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Stuebe, A. M., Landon, M. B., Lai, Y., Spong, C. Y., Carpenter, M. W., Ramin, S. M., Casey, B., Wapner, R. J., Varner, M. W., Rouse, D. J., Sciscione, A., Catalano, P., Harper, M., Saade, G., Sorokin, Y., Peaceman, A. M., & Tolosa, J. E. (2012). Maternal BMI, glucose tolerance, and adverse pregnancy outcomes. American journal of obstetrics and gynecology, 207(1), 62.e1-62.e7. https://doi.org/10.1016/j.ajog.2012.04.035