Maternal Death Due to Clostridium novyi in an Injection Drug User

Christina Herrera, Ryan Meehan, Varsha Podduturi, Alexander Eastman, David B Nelson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUND: Soft-tissue infections in women with subcutaneous injection drug use are often polymicrobial. CASE: A 21-year-old nulliparous woman presented at 14-15 weeks of gestation with several gluteal abscesses related to subcutaneous injection of heroin. She was well appearing, afebrile, and without findings of systemic illness. After empiric broad-spectrum intravenous antibiotics, same-day incision and drainage was performed. Immediately after the procedure, she developed refractory hypotension, severe tachycardia, pulmonary edema, and leukemoid reaction (white blood cell count 80×10 9 /L). Cardiac arrest ensued, and she died within 4 hours of onset of sepsis and within 24 hours of presentation. Wound cultures identified Clostridium novyi. CONCLUSION: Local, soft-tissue infections that includes C novyi can result in rapidly fatal, toxin-mediated septic shock in pregnant women with high-risk social behavior.

Original languageEnglish (US)
Pages (from-to)876-879
Number of pages4
JournalObstetrics and Gynecology
Volume128
Issue number4
DOIs
StatePublished - Oct 1 2016

Fingerprint

Maternal Death
Soft Tissue Infections
Clostridium
Subcutaneous Injections
Drug Users
Leukemoid Reaction
Injections
Social Behavior
Heroin
Pulmonary Edema
Septic Shock
Risk-Taking
Heart Arrest
Leukocyte Count
Tachycardia
Hypotension
Abscess
Pregnant Women
Drainage
Sepsis

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Maternal Death Due to Clostridium novyi in an Injection Drug User. / Herrera, Christina; Meehan, Ryan; Podduturi, Varsha; Eastman, Alexander; Nelson, David B.

In: Obstetrics and Gynecology, Vol. 128, No. 4, 01.10.2016, p. 876-879.

Research output: Contribution to journalArticle

Herrera, Christina ; Meehan, Ryan ; Podduturi, Varsha ; Eastman, Alexander ; Nelson, David B. / Maternal Death Due to Clostridium novyi in an Injection Drug User. In: Obstetrics and Gynecology. 2016 ; Vol. 128, No. 4. pp. 876-879.
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