Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children

MacKinsey K.A. Christian, Maureen Samms-Vaughan, Min Jae Lee, Jan Bressler, Manouchehr Hessabi, Megan L. Grove, Sydonnie Shakespeare-Pellington, Charlene Coore Desai, Jody Ann Reece, Katherine A. Loveland, Eric Boerwinkle, Mohammad H. Rahbar

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74–5.60), physical trauma (MOR 2.02, 95% CI 1.01–4.05), and oil-based paints (MOR 1.99, 95% CI 1.14–3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD.

Original languageEnglish (US)
Pages (from-to)2766-2778
Number of pages13
JournalJournal of Autism and Developmental Disorders
Volume48
Issue number8
DOIs
StatePublished - Aug 1 2018
Externally publishedYes

Keywords

  • Autism spectrum disorder
  • Fever
  • Jamaica
  • Pesticides
  • Physical trauma
  • Volatile organic compounds

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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