TY - JOUR
T1 - Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children
AU - Christian, MacKinsey K.A.
AU - Samms-Vaughan, Maureen
AU - Lee, Min Jae
AU - Bressler, Jan
AU - Hessabi, Manouchehr
AU - Grove, Megan L.
AU - Shakespeare-Pellington, Sydonnie
AU - Coore Desai, Charlene
AU - Reece, Jody Ann
AU - Loveland, Katherine A.
AU - Boerwinkle, Eric
AU - Rahbar, Mohammad H.
N1 - Funding Information:
Acknowledgments This research is co-funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institutes of Health Fogarty International Center (NIH-FIC) by a grant (R21HD057808) as well as National Institute of Environmental Health Sciences (NIEHS) by a grant (R01ES022165) awarded to The University of Texas Health Science Center at Houston. We also acknowledge the support provided by the Biostatistics/Epidemiology/Research Design (BERD) component of the Center for Clinical and Translational Sciences (CCTS) for this project. CCTS is mainly funded by the NIH Centers for Translational Science Award (NIH CTSA) grant (UL1 RR024148), awarded to The University of Texas Health Science Center at Houston in 2006 by the National Center for Research Resources (NCRR) and its renewal (UL1 TR000371) by the National Center for Advancing Translational Sciences (NCATS). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NICHD or the NIH-FIC or NIEHS or the NCRR or the NCATS. This manuscript was prepared from the Master’s thesis completed by MacKinsey A. Christian.
Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74–5.60), physical trauma (MOR 2.02, 95% CI 1.01–4.05), and oil-based paints (MOR 1.99, 95% CI 1.14–3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD.
AB - Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74–5.60), physical trauma (MOR 2.02, 95% CI 1.01–4.05), and oil-based paints (MOR 1.99, 95% CI 1.14–3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD.
KW - Autism spectrum disorder
KW - Fever
KW - Jamaica
KW - Pesticides
KW - Physical trauma
KW - Volatile organic compounds
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U2 - 10.1007/s10803-018-3537-6
DO - 10.1007/s10803-018-3537-6
M3 - Article
C2 - 29549549
AN - SCOPUS:85044043802
SN - 0162-3257
VL - 48
SP - 2766
EP - 2778
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 8
ER -