Maternal microbial factors that affect the fetus and subsequent offspring

Julie Mirpuri, Josef Neu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The maternal microbiome has emerged as an important area of investigation. While birth is a critical timepoint for initial colonization of the newborn, the fetus resides in the womb surrounded by multiple unique colonized niches. The maternal microbiome has recently been shown to be associated with several morbidities in offspring. Understanding the multiple bacterial niches within the pregnant woman and how they interact with the fetus in-utero can lead to novel therapies to improve the health of offspring. In this review, we provide an overview of the available literature on normal bacterial colonization within the individual niches of the pregnant woman and the known associations with outcomes in offspring, including a discussion of the controversy of in-utero colonization.

Original languageEnglish (US)
Article number151449
JournalSeminars in Perinatology
Volume45
Issue number6
DOIs
StatePublished - Oct 2021

Keywords

  • fetus
  • Maternal
  • microbiome
  • offspring
  • probiotics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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