Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study

Philip J. Lupo, Elaine Symanski, Peter H. Langlois, Christina C. Lawson, Sadia Malik, Suzanne M. Gilboa, Laura J. Lee, A. J. Agopian, Tania A. Desrosiers, Martha A. Waters, Paul A. Romitti, Adolfo Correa, Gary M. Shaw, Laura E. Mitchell

Research output: Contribution to journalArticle

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Abstract

BACKGROUND:There is evidence in experimental model systems that exposure to polycyclic aromatic hydrocarbons (PAHs) results in congenital heart defects (CHDs); however, to our knowledge, this relationship has not been examined in humans. Therefore, we conducted a case-control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs in offspring. METHODS:Data on CHD cases and control infants were obtained from the National Birth Defects Prevention Study for the period of 1997 to 2002. Exposure to PAHs was assigned by industrial hygienist consensus, based on self-reported maternal occupational histories from 1 month before conception through the third month of pregnancy. Logistic regression was used to evaluate the association between maternal occupational PAH exposure and specific CHD phenotypic subtypes among offspring. RESULTS:The prevalence of occupational PAH exposure was 4.0% in CHD case mothers (76/1907) and 3.6% in control mothers (104/2853). After adjusting for maternal age, race or ethnicity, education, smoking, folic acid supplementation, and study center, exposure was not associated with conotruncal defects (adjusted odds ratio [AOR], 0.98; 95% confidence interval [CI], 0.58-1.67), septal defects (AOR, 1.28; 95% CI, 0.86-1.90), or with any isolated CHD subtype. CONCLUSIONS:Our findings do not support an association between potential maternal occupational exposure to PAHs and various CHDs in a large, population-based study. For CHD phenotypic subtypes in which modest nonsignificant associations were observed, future investigations could be improved by studying populations with a higher prevalence of PAH exposure and by incorporating information on maternal and fetal genotypes related to PAH metabolism.

Original languageEnglish (US)
Pages (from-to)875-881
Number of pages7
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Volume94
Issue number11
DOIs
StatePublished - Nov 1 2012

Fingerprint

Maternal Exposure
Congenital Heart Defects
Polycyclic Aromatic Hydrocarbons
Occupational Exposure
Mothers
Odds Ratio
Confidence Intervals
Maternal Age
Folic Acid
Population
Case-Control Studies
Consensus
Theoretical Models
Logistic Models
Smoking
Genotype
Education
Pregnancy

Keywords

  • Birth defects
  • Congenital heart defects
  • Epidemiology
  • Maternal occupation
  • Polycyclic aromatic hydrocarbons

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Developmental Biology

Cite this

Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study. / Lupo, Philip J.; Symanski, Elaine; Langlois, Peter H.; Lawson, Christina C.; Malik, Sadia; Gilboa, Suzanne M.; Lee, Laura J.; Agopian, A. J.; Desrosiers, Tania A.; Waters, Martha A.; Romitti, Paul A.; Correa, Adolfo; Shaw, Gary M.; Mitchell, Laura E.

In: Birth Defects Research Part A - Clinical and Molecular Teratology, Vol. 94, No. 11, 01.11.2012, p. 875-881.

Research output: Contribution to journalArticle

Lupo, PJ, Symanski, E, Langlois, PH, Lawson, CC, Malik, S, Gilboa, SM, Lee, LJ, Agopian, AJ, Desrosiers, TA, Waters, MA, Romitti, PA, Correa, A, Shaw, GM & Mitchell, LE 2012, 'Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study', Birth Defects Research Part A - Clinical and Molecular Teratology, vol. 94, no. 11, pp. 875-881. https://doi.org/10.1002/bdra.23071
Lupo, Philip J. ; Symanski, Elaine ; Langlois, Peter H. ; Lawson, Christina C. ; Malik, Sadia ; Gilboa, Suzanne M. ; Lee, Laura J. ; Agopian, A. J. ; Desrosiers, Tania A. ; Waters, Martha A. ; Romitti, Paul A. ; Correa, Adolfo ; Shaw, Gary M. ; Mitchell, Laura E. / Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study. In: Birth Defects Research Part A - Clinical and Molecular Teratology. 2012 ; Vol. 94, No. 11. pp. 875-881.
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abstract = "BACKGROUND:There is evidence in experimental model systems that exposure to polycyclic aromatic hydrocarbons (PAHs) results in congenital heart defects (CHDs); however, to our knowledge, this relationship has not been examined in humans. Therefore, we conducted a case-control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs in offspring. METHODS:Data on CHD cases and control infants were obtained from the National Birth Defects Prevention Study for the period of 1997 to 2002. Exposure to PAHs was assigned by industrial hygienist consensus, based on self-reported maternal occupational histories from 1 month before conception through the third month of pregnancy. Logistic regression was used to evaluate the association between maternal occupational PAH exposure and specific CHD phenotypic subtypes among offspring. RESULTS:The prevalence of occupational PAH exposure was 4.0{\%} in CHD case mothers (76/1907) and 3.6{\%} in control mothers (104/2853). After adjusting for maternal age, race or ethnicity, education, smoking, folic acid supplementation, and study center, exposure was not associated with conotruncal defects (adjusted odds ratio [AOR], 0.98; 95{\%} confidence interval [CI], 0.58-1.67), septal defects (AOR, 1.28; 95{\%} CI, 0.86-1.90), or with any isolated CHD subtype. CONCLUSIONS:Our findings do not support an association between potential maternal occupational exposure to PAHs and various CHDs in a large, population-based study. For CHD phenotypic subtypes in which modest nonsignificant associations were observed, future investigations could be improved by studying populations with a higher prevalence of PAH exposure and by incorporating information on maternal and fetal genotypes related to PAH metabolism.",
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author = "Lupo, {Philip J.} and Elaine Symanski and Langlois, {Peter H.} and Lawson, {Christina C.} and Sadia Malik and Gilboa, {Suzanne M.} and Lee, {Laura J.} and Agopian, {A. J.} and Desrosiers, {Tania A.} and Waters, {Martha A.} and Romitti, {Paul A.} and Adolfo Correa and Shaw, {Gary M.} and Mitchell, {Laura E.}",
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T1 - Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study

AU - Lupo, Philip J.

AU - Symanski, Elaine

AU - Langlois, Peter H.

AU - Lawson, Christina C.

AU - Malik, Sadia

AU - Gilboa, Suzanne M.

AU - Lee, Laura J.

AU - Agopian, A. J.

AU - Desrosiers, Tania A.

AU - Waters, Martha A.

AU - Romitti, Paul A.

AU - Correa, Adolfo

AU - Shaw, Gary M.

AU - Mitchell, Laura E.

PY - 2012/11/1

Y1 - 2012/11/1

N2 - BACKGROUND:There is evidence in experimental model systems that exposure to polycyclic aromatic hydrocarbons (PAHs) results in congenital heart defects (CHDs); however, to our knowledge, this relationship has not been examined in humans. Therefore, we conducted a case-control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs in offspring. METHODS:Data on CHD cases and control infants were obtained from the National Birth Defects Prevention Study for the period of 1997 to 2002. Exposure to PAHs was assigned by industrial hygienist consensus, based on self-reported maternal occupational histories from 1 month before conception through the third month of pregnancy. Logistic regression was used to evaluate the association between maternal occupational PAH exposure and specific CHD phenotypic subtypes among offspring. RESULTS:The prevalence of occupational PAH exposure was 4.0% in CHD case mothers (76/1907) and 3.6% in control mothers (104/2853). After adjusting for maternal age, race or ethnicity, education, smoking, folic acid supplementation, and study center, exposure was not associated with conotruncal defects (adjusted odds ratio [AOR], 0.98; 95% confidence interval [CI], 0.58-1.67), septal defects (AOR, 1.28; 95% CI, 0.86-1.90), or with any isolated CHD subtype. CONCLUSIONS:Our findings do not support an association between potential maternal occupational exposure to PAHs and various CHDs in a large, population-based study. For CHD phenotypic subtypes in which modest nonsignificant associations were observed, future investigations could be improved by studying populations with a higher prevalence of PAH exposure and by incorporating information on maternal and fetal genotypes related to PAH metabolism.

AB - BACKGROUND:There is evidence in experimental model systems that exposure to polycyclic aromatic hydrocarbons (PAHs) results in congenital heart defects (CHDs); however, to our knowledge, this relationship has not been examined in humans. Therefore, we conducted a case-control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs in offspring. METHODS:Data on CHD cases and control infants were obtained from the National Birth Defects Prevention Study for the period of 1997 to 2002. Exposure to PAHs was assigned by industrial hygienist consensus, based on self-reported maternal occupational histories from 1 month before conception through the third month of pregnancy. Logistic regression was used to evaluate the association between maternal occupational PAH exposure and specific CHD phenotypic subtypes among offspring. RESULTS:The prevalence of occupational PAH exposure was 4.0% in CHD case mothers (76/1907) and 3.6% in control mothers (104/2853). After adjusting for maternal age, race or ethnicity, education, smoking, folic acid supplementation, and study center, exposure was not associated with conotruncal defects (adjusted odds ratio [AOR], 0.98; 95% confidence interval [CI], 0.58-1.67), septal defects (AOR, 1.28; 95% CI, 0.86-1.90), or with any isolated CHD subtype. CONCLUSIONS:Our findings do not support an association between potential maternal occupational exposure to PAHs and various CHDs in a large, population-based study. For CHD phenotypic subtypes in which modest nonsignificant associations were observed, future investigations could be improved by studying populations with a higher prevalence of PAH exposure and by incorporating information on maternal and fetal genotypes related to PAH metabolism.

KW - Birth defects

KW - Congenital heart defects

KW - Epidemiology

KW - Maternal occupation

KW - Polycyclic aromatic hydrocarbons

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