Maternal periodontal disease is associated with oxidative stress during pregnancy

M. Ashley Hickman, Kim A. Boggess, Kevin L. Moss, James D. Beck, Steven Offenbacher

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We sought to determine if maternal periodontal disease is associated with oxidative stress as measured by serum 8-isoprostane. A secondary analysis was conducted using prospective data from the Oral Conditions and Pregnancy Study. Healthy women enrolled at < 26 weeks' gestational age underwent oral examination and serum sampling. Maternal periodontal disease status was categorized as healthy, mild, or moderate to severe by clinical criteria. Maternal serum was analyzed for 8-isoprostane using ultrasensitive enzyme-linked immunosorbent assay. Elevated 8-isoprostane level was defined as ≥75th percentile. Maternal factors associated with elevated 8-isoprostane were determined using chi-square or t test. Multivariable logistic regression was used to assess association between elevated 8-isoprostane and maternal factors. Seven hundred ninety-one women had complete data. Median (interquartile) 8-isoprostane serum level was 1806 (16 to 81,870) pg/dL. Using bivariate analysis, maternal age, race, marital status, utilization of public assistance, and mild or moderate to severe periodontal disease were associated with elevated serum 8-isoprostane. Using logistic regression, moderate to severe periodontal disease (adjusted odds ratio 2.9, 95% confidence interval: 1.7 to 5.0) remained significantly associated with an elevated serum 8-isoprostane level. Maternal periodontal disease is associated with oxidative stress during pregnancy. Further study is needed to determine the role of maternal oxidative stress in periodontal disease-associated adverse pregnancy outcomes.

Original languageEnglish (US)
Pages (from-to)247-251
Number of pages5
JournalAmerican Journal of Perinatology
Volume28
Issue number3
DOIs
StatePublished - 2011

Fingerprint

8-epi-prostaglandin F2alpha
Periodontal Diseases
Oxidative Stress
Mothers
Pregnancy
Serum
Logistic Models
Public Assistance
Oral Diagnosis
Maternal Age
Marital Status
Pregnancy Outcome

Keywords

  • 8-isoprostane
  • biomarker
  • oxidative stress
  • Periodontal disease
  • pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Maternal periodontal disease is associated with oxidative stress during pregnancy. / Hickman, M. Ashley; Boggess, Kim A.; Moss, Kevin L.; Beck, James D.; Offenbacher, Steven.

In: American Journal of Perinatology, Vol. 28, No. 3, 2011, p. 247-251.

Research output: Contribution to journalArticle

Hickman, M. Ashley ; Boggess, Kim A. ; Moss, Kevin L. ; Beck, James D. ; Offenbacher, Steven. / Maternal periodontal disease is associated with oxidative stress during pregnancy. In: American Journal of Perinatology. 2011 ; Vol. 28, No. 3. pp. 247-251.
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