Maternal use of hot tub and major structural birth defects

Hao T. Duong, Syed Shahrukh Hashmi, Tunu Ramadhani, Mark A. Canfield, Angela Scheuerle, Dorothy Kim Waller

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Previous studies on the associations between hot tub use during early pregnancy and birth defects have found an increased risk of neural tube defects, but no increase in risk of cardiac defects. No previous studies have assessed the association between maternal hot tub use and other types of noncardiac birth defects. Methods: We included mothers of infants with birth defects (n = 10,825) and mothers of infants without birth defects (n = 6795) who participated in the multisite National Birth Defects Prevention Study between 1997 and 2005. Odds ratios were adjusted for maternal ethnicity and education. Results: Analysis of 17 birth defects revealed that mothers of infants with gastroschisis and anencephaly were significantly more likely to report any use of a hot tub in early pregnancy: adjusted odd ratios were 1.54 (95% confidence interval [CI], 1.10-2.17) and 1.68 (95% CI, 1.05-2.70), respectively. Among the mothers who reported using a hot tub more than once in the exposure period and remaining in it for more than 30 min, we found significantly elevated odds ratios (≥2.0) for esophageal atresia, omphalocele, and gastroschisis and a nonsignificant elevation (≥2.0) for spina bifida and anencephaly. Conclusions: These results suggest that women who use hot tubs more than once during early pregnancy and for long periods of time have an increased risk of certain birth defect phenotypes, particularly anencephaly and gastroschisis. Because of multiple statistical tests and small sample sizes, we cannot exclude the possibility that some of these elevated associations may be due to chance.

Original languageEnglish (US)
Pages (from-to)836-841
Number of pages6
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Volume91
Issue number9
DOIs
StatePublished - Sep 2011

Fingerprint

Mothers
Gastroschisis
Anencephaly
Odds Ratio
Pregnancy
Confidence Intervals
Esophageal Atresia
Umbilical Hernia
Neural Tube Defects
Sample Size
Phenotype
Education

Keywords

  • Birth defects
  • Congenital malformations
  • Gastroschisis
  • Hot tub
  • Hyperthermia
  • Neural tube defects

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health
  • Embryology

Cite this

Maternal use of hot tub and major structural birth defects. / Duong, Hao T.; Shahrukh Hashmi, Syed; Ramadhani, Tunu; Canfield, Mark A.; Scheuerle, Angela; Kim Waller, Dorothy.

In: Birth Defects Research Part A - Clinical and Molecular Teratology, Vol. 91, No. 9, 09.2011, p. 836-841.

Research output: Contribution to journalArticle

Duong, HT, Shahrukh Hashmi, S, Ramadhani, T, Canfield, MA, Scheuerle, A & Kim Waller, D 2011, 'Maternal use of hot tub and major structural birth defects', Birth Defects Research Part A - Clinical and Molecular Teratology, vol. 91, no. 9, pp. 836-841. https://doi.org/10.1002/bdra.20831
Duong, Hao T. ; Shahrukh Hashmi, Syed ; Ramadhani, Tunu ; Canfield, Mark A. ; Scheuerle, Angela ; Kim Waller, Dorothy. / Maternal use of hot tub and major structural birth defects. In: Birth Defects Research Part A - Clinical and Molecular Teratology. 2011 ; Vol. 91, No. 9. pp. 836-841.
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