Maternally transmitted antigen of mice

A model transplantation antigen

K. Fischer Lindahl, E. Hermel, B. E. Loveland, C. R. Wang

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Molecular identification proved Mta, the maternally transmitted antigen of mice, to be a model minor histocompatibility (H) antigen. It consists of a peptide, MTF, that is presented on the cell surface by an H-2 class-I molecule, HMT. MTF is derived from ND1, a mitochondrially encoded protein, and the amino-terminal N-formyl-methionine is essential for binding to HMT; conservative substitutions at the sixth residue causes MTF to be a minor H antigen. HMT is encoded by the M3 gene at the telomeric end of the H-2 complex. The peptide-binding site of HMT is hydrophobic, and allelic forms of the mature protein differ by only three amino acids. Homologues and analogues of the mouse Mta system have recently been identified in rats.

Original languageEnglish (US)
Pages (from-to)351-372
Number of pages22
JournalAnnual Review of Immunology
Volume9
Issue number1
StatePublished - 1991

Fingerprint

Histocompatibility Antigens
Minor Histocompatibility Antigens
Peptides
Methionine
Proteins
Binding Sites
Amino Acids
Genes
Mouse Mta antigen
H antigen

Keywords

  • Antigen presentation
  • Class-I molecules
  • Cytotoxic T lymphocytes
  • Major histocompatibility complex
  • Mitochondria

ASJC Scopus subject areas

  • Immunology

Cite this

Fischer Lindahl, K., Hermel, E., Loveland, B. E., & Wang, C. R. (1991). Maternally transmitted antigen of mice: A model transplantation antigen. Annual Review of Immunology, 9(1), 351-372.

Maternally transmitted antigen of mice : A model transplantation antigen. / Fischer Lindahl, K.; Hermel, E.; Loveland, B. E.; Wang, C. R.

In: Annual Review of Immunology, Vol. 9, No. 1, 1991, p. 351-372.

Research output: Contribution to journalArticle

Fischer Lindahl, K, Hermel, E, Loveland, BE & Wang, CR 1991, 'Maternally transmitted antigen of mice: A model transplantation antigen', Annual Review of Immunology, vol. 9, no. 1, pp. 351-372.
Fischer Lindahl K, Hermel E, Loveland BE, Wang CR. Maternally transmitted antigen of mice: A model transplantation antigen. Annual Review of Immunology. 1991;9(1):351-372.
Fischer Lindahl, K. ; Hermel, E. ; Loveland, B. E. ; Wang, C. R. / Maternally transmitted antigen of mice : A model transplantation antigen. In: Annual Review of Immunology. 1991 ; Vol. 9, No. 1. pp. 351-372.
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