Mathematical and experimental methods for design and evaluation of membrane oxygenators

R. C. Eberhart, S. K. Dengle, R. M. Curtis

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Three categories of membrane oxygenators are considered: passive flow, secondary flow induced by the mainstream, secondary flow induced by an external application of energy. The current status of mathematical methods for analysis of fluid mechanics, O2 and CO2 exchange for these categories are briefly reviewed. Emphasis is given to approximate methods for calculation of gas exchange. Practical methods for experimental design optimization studies are outlined; these methods are extended to evaluation of O2 and CO2 exchange in clinical operation. A new method for estimation of internal ventilation and perfusion maldistribution and diffusion resistance is described. A brief assessment of blood damage in clinical application of the oxygenator is presented from the point of view of deterioration of gas exchange performance.

Original languageEnglish (US)
Pages (from-to)19-34
Number of pages16
JournalArtificial Organs
Volume2
Issue number1
StatePublished - 1978

Fingerprint

Oxygenators
Membrane Oxygenators
Secondary flow
Research Design
Gases
Membranes
Fluid mechanics
Design of experiments
Ventilation
Deterioration
Blood
Mechanics
Perfusion

ASJC Scopus subject areas

  • Biophysics

Cite this

Eberhart, R. C., Dengle, S. K., & Curtis, R. M. (1978). Mathematical and experimental methods for design and evaluation of membrane oxygenators. Artificial Organs, 2(1), 19-34.

Mathematical and experimental methods for design and evaluation of membrane oxygenators. / Eberhart, R. C.; Dengle, S. K.; Curtis, R. M.

In: Artificial Organs, Vol. 2, No. 1, 1978, p. 19-34.

Research output: Contribution to journalArticle

Eberhart, RC, Dengle, SK & Curtis, RM 1978, 'Mathematical and experimental methods for design and evaluation of membrane oxygenators', Artificial Organs, vol. 2, no. 1, pp. 19-34.
Eberhart, R. C. ; Dengle, S. K. ; Curtis, R. M. / Mathematical and experimental methods for design and evaluation of membrane oxygenators. In: Artificial Organs. 1978 ; Vol. 2, No. 1. pp. 19-34.
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