Mathematical and Experimental Methods for Design and Evaluation of Membrane Oxygenators

R. C. Eberhart; S. K. Dengle; R. M. Curtis

doi:10.1111/j.1525-1594.1978.tb00999.x

Mathematical and Experimental Methods for Design and Evaluation of Membrane Oxygenators

R. C. Eberhart, S. K. Dengle, R. M. Curtis

Surgery

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18 Scopus citations

Abstract

Three categories of membrane oxygenators are considered: passive flow, secondary flow induced by the mainstream, secondary flow induced by an external application of energy. The current status of mathematical methods for analysis of fluid mechanics, O₂ and CO₂ exchange for these categories are briefly reviewed. Emphasis is given to approximate methods for calculation of gas exchange. Practical methods for experimental design optimization studies are outlined; these methods are extended to evaluation of O₂ and CO₂ exchange in clinical operation. A new method for estimation of internal ventilation and perfusion maldistribution and diffusion resistance is described. A brief assessment of blood damage in clinical application of the oxygenator is presented from the point of view of deterioration of gas exchange performance.

Original language	English (US)
Pages (from-to)	19-34
Number of pages	16
Journal	Artificial Organs
Volume	2
Issue number	1
DOIs	https://doi.org/10.1111/j.1525-1594.1978.tb00999.x
State	Published - Feb 1978

Keywords

blood oxygenation
fluid mechanics
gas exchange
membrane oxygenator

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

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10.1111/j.1525-1594.1978.tb00999.x

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AB - Three categories of membrane oxygenators are considered: passive flow, secondary flow induced by the mainstream, secondary flow induced by an external application of energy. The current status of mathematical methods for analysis of fluid mechanics, O2 and CO2 exchange for these categories are briefly reviewed. Emphasis is given to approximate methods for calculation of gas exchange. Practical methods for experimental design optimization studies are outlined; these methods are extended to evaluation of O2 and CO2 exchange in clinical operation. A new method for estimation of internal ventilation and perfusion maldistribution and diffusion resistance is described. A brief assessment of blood damage in clinical application of the oxygenator is presented from the point of view of deterioration of gas exchange performance.

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Mathematical and Experimental Methods for Design and Evaluation of Membrane Oxygenators

Abstract

Keywords

ASJC Scopus subject areas

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