Maturation of Executive Function in Autism

Beatriz Luna, Sara K. Doll, Stephen J. Hegedus, Nancy J. Minshew, John A. Sweeney

Research output: Contribution to journalArticle

192 Scopus citations

Abstract

Background: Executive dysfunction has been reported at different ages in autism. It is not clear however, when this impairment emerges or how its expression is affected by development. Methods: 61 non-mentally retarded autism participants (AUT) and 61 age, gender, and IQ matched typically developing participants (CON) were assessed with two oculomotor executive function tasks, the oculomotor delayed response task (ODR) and the antisaccade task (AS), as well as a visually-guided saccade sensorimotor task (VGS). Results: The AUT group demonstrated impairments in response inhibition and spatial working memory at all ages tested. Developmental improvements in speed of sensorimotor processing and voluntary response inhibition were similar in both groups indicating sparing of some attentional control of behavior. Developmental progression in the speed of initiating a cognitive plan and maintaining information on line over time, however, was impaired in the AUT group indicating abnormal development of working memory. Conclusions: These results indicate that while executive dysfunction is present throughout development, there is evidence for both typical and atypical developmental progression of executive functions in autism. The plasticity suggested by the developmental improvements may have implications regarding appropriate developmental epochs and types of interventions aimed at enhancing cognitive capacities in individuals with autism.

Original languageEnglish (US)
Pages (from-to)474-481
Number of pages8
JournalBiological Psychiatry
Volume61
Issue number4
DOIs
StatePublished - Feb 15 2007

Keywords

  • Antisaccade
  • cognition
  • development
  • inhibition
  • prefrontal cortex
  • spatial working memory

ASJC Scopus subject areas

  • Biological Psychiatry

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    Luna, B., Doll, S. K., Hegedus, S. J., Minshew, N. J., & Sweeney, J. A. (2007). Maturation of Executive Function in Autism. Biological Psychiatry, 61(4), 474-481. https://doi.org/10.1016/j.biopsych.2006.02.030