Maturation of proximal straight tubule NaCl transport: Role of thyroid hormone

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We have recently demonstrated that the rates of both active and passive proximal straight tubule (PST) NaCl transport in neonatal rabbits were less than in adults. In this segment NaCl entry across the apical membrane is via parallel Na+/H+ and Cl-/OH- exchangers, which increases in activity with maturation. The present in vitro microperfusion study examined whether thyroid hormone plays a role in the maturational increase in PST NaCl transport. Neonatal and adult PST were perfused with a high-chloride-low bicarbonate solution without organic solutes, simulating late proximal tubule fluid. Thyroid hormone-treated neonates had a higher rate of PST total and passive NaCl transport. In 8-wk-old animals that were hypothyroid since birth, the maturational increase in total and passive NaCl transport was prevented. Thyroid treatment for 4 days in hypothyroid 8-wk-old rabbits increased the rate of both total and passive NaCl transport. The maturational increases in both Na+/H+ and Cl-/OHexchange activities were blunted in 8- wk-old hypothyroid animals and increased to control levels with thyroid treatment. This study demonstrates that thyroid hormone is a factor responsible for the maturational increase in both active and passive PST NaCl transport.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Physiology
Volume278
Issue number4 47-4
StatePublished - Apr 2000

Fingerprint

Thyroid Hormones
Thyroid Gland
Rabbits
Bicarbonates
Chlorides
Parturition
Membranes

Keywords

  • Chloride/base exchanger
  • Kidney development
  • Passive transport
  • Sodium/hydrogen antiporter

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

@article{27ad40f8ea0e4b2eb96972fae52affca,
title = "Maturation of proximal straight tubule NaCl transport: Role of thyroid hormone",
abstract = "We have recently demonstrated that the rates of both active and passive proximal straight tubule (PST) NaCl transport in neonatal rabbits were less than in adults. In this segment NaCl entry across the apical membrane is via parallel Na+/H+ and Cl-/OH- exchangers, which increases in activity with maturation. The present in vitro microperfusion study examined whether thyroid hormone plays a role in the maturational increase in PST NaCl transport. Neonatal and adult PST were perfused with a high-chloride-low bicarbonate solution without organic solutes, simulating late proximal tubule fluid. Thyroid hormone-treated neonates had a higher rate of PST total and passive NaCl transport. In 8-wk-old animals that were hypothyroid since birth, the maturational increase in total and passive NaCl transport was prevented. Thyroid treatment for 4 days in hypothyroid 8-wk-old rabbits increased the rate of both total and passive NaCl transport. The maturational increases in both Na+/H+ and Cl-/OHexchange activities were blunted in 8- wk-old hypothyroid animals and increased to control levels with thyroid treatment. This study demonstrates that thyroid hormone is a factor responsible for the maturational increase in both active and passive PST NaCl transport.",
keywords = "Chloride/base exchanger, Kidney development, Passive transport, Sodium/hydrogen antiporter",
author = "Mehul Shah and Raymond Quigley and Michel Baum",
year = "2000",
month = "4",
language = "English (US)",
volume = "278",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "4 47-4",

}

TY - JOUR

T1 - Maturation of proximal straight tubule NaCl transport

T2 - Role of thyroid hormone

AU - Shah, Mehul

AU - Quigley, Raymond

AU - Baum, Michel

PY - 2000/4

Y1 - 2000/4

N2 - We have recently demonstrated that the rates of both active and passive proximal straight tubule (PST) NaCl transport in neonatal rabbits were less than in adults. In this segment NaCl entry across the apical membrane is via parallel Na+/H+ and Cl-/OH- exchangers, which increases in activity with maturation. The present in vitro microperfusion study examined whether thyroid hormone plays a role in the maturational increase in PST NaCl transport. Neonatal and adult PST were perfused with a high-chloride-low bicarbonate solution without organic solutes, simulating late proximal tubule fluid. Thyroid hormone-treated neonates had a higher rate of PST total and passive NaCl transport. In 8-wk-old animals that were hypothyroid since birth, the maturational increase in total and passive NaCl transport was prevented. Thyroid treatment for 4 days in hypothyroid 8-wk-old rabbits increased the rate of both total and passive NaCl transport. The maturational increases in both Na+/H+ and Cl-/OHexchange activities were blunted in 8- wk-old hypothyroid animals and increased to control levels with thyroid treatment. This study demonstrates that thyroid hormone is a factor responsible for the maturational increase in both active and passive PST NaCl transport.

AB - We have recently demonstrated that the rates of both active and passive proximal straight tubule (PST) NaCl transport in neonatal rabbits were less than in adults. In this segment NaCl entry across the apical membrane is via parallel Na+/H+ and Cl-/OH- exchangers, which increases in activity with maturation. The present in vitro microperfusion study examined whether thyroid hormone plays a role in the maturational increase in PST NaCl transport. Neonatal and adult PST were perfused with a high-chloride-low bicarbonate solution without organic solutes, simulating late proximal tubule fluid. Thyroid hormone-treated neonates had a higher rate of PST total and passive NaCl transport. In 8-wk-old animals that were hypothyroid since birth, the maturational increase in total and passive NaCl transport was prevented. Thyroid treatment for 4 days in hypothyroid 8-wk-old rabbits increased the rate of both total and passive NaCl transport. The maturational increases in both Na+/H+ and Cl-/OHexchange activities were blunted in 8- wk-old hypothyroid animals and increased to control levels with thyroid treatment. This study demonstrates that thyroid hormone is a factor responsible for the maturational increase in both active and passive PST NaCl transport.

KW - Chloride/base exchanger

KW - Kidney development

KW - Passive transport

KW - Sodium/hydrogen antiporter

UR - http://www.scopus.com/inward/record.url?scp=0034003849&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034003849&partnerID=8YFLogxK

M3 - Article

C2 - 10751220

AN - SCOPUS:0034003849

VL - 278

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

IS - 4 47-4

ER -