Maturation of widely distributed brain function subserves cognitive development

Beatriz Luna; Keith R. Thulborn; Douglas P. Munoz; Elisha P. Merriam; Krista E. Garver; Nancy J. Minshew; Matcheri S. Keshavan; Christopher R. Genovese; William F. Eddy; John A. Sweeney

doi:10.1006/nimg.2000.0743

Maturation of widely distributed brain function subserves cognitive development

Beatriz Luna, Keith R. Thulborn, Douglas P. Munoz, Elisha P. Merriam, Krista E. Garver, Nancy J. Minshew, Matcheri S. Keshavan, Christopher R. Genovese, William F. Eddy, John A. Sweeney

Research output: Contribution to journal › Article › peer-review

574 Scopus citations

Abstract

Cognitive and brain maturational changes continue throughout late childhood and adolescence. During this time, increasing cognitive control over behavior enhances the voluntary suppression of reflexive/impulsive response tendencies. Recently, with the advent of functional MRI, it has become possible to characterize changes in brain activity during cognitive development. In order to investigate the cognitive and brain maturation subserving the ability to voluntarily suppress context-inappropriate behavior, we tested 8-30 year olds in an oculomotor response-suppression task. Behavioral results indicated that adult-like ability to inhibit prepotent responses matured gradually through childhood and adolescence. Functional MRI results indicated that brain activation in frontal, parietal, striatal, and thalamic regions increased progressively from childhood to adulthood. Prefrontal cortex was more active in adolescents than in children or adults; adults demonstrated greater activation in the lateral cerebellum than younger subjects. These results suggest that efficient top-down modulation of reflexive acts may not be fully developed until adulthood and provide evidence that maturation of function across widely distributed brain regions lays the groundwork for enhanced voluntary control of behavior during cognitive development.

Original language	English (US)
Pages (from-to)	786-793
Number of pages	8
Journal	NeuroImage
Volume	13
Issue number	5
DOIs	https://doi.org/10.1006/nimg.2000.0743
State	Published - 2001

Keywords

Cerebellum
Eye movements
Inhibition
Neuroimaging

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1006/nimg.2000.0743

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@article{b48c4ce67db84a4eb5954bf64e575860,

title = "Maturation of widely distributed brain function subserves cognitive development",

abstract = "Cognitive and brain maturational changes continue throughout late childhood and adolescence. During this time, increasing cognitive control over behavior enhances the voluntary suppression of reflexive/impulsive response tendencies. Recently, with the advent of functional MRI, it has become possible to characterize changes in brain activity during cognitive development. In order to investigate the cognitive and brain maturation subserving the ability to voluntarily suppress context-inappropriate behavior, we tested 8-30 year olds in an oculomotor response-suppression task. Behavioral results indicated that adult-like ability to inhibit prepotent responses matured gradually through childhood and adolescence. Functional MRI results indicated that brain activation in frontal, parietal, striatal, and thalamic regions increased progressively from childhood to adulthood. Prefrontal cortex was more active in adolescents than in children or adults; adults demonstrated greater activation in the lateral cerebellum than younger subjects. These results suggest that efficient top-down modulation of reflexive acts may not be fully developed until adulthood and provide evidence that maturation of function across widely distributed brain regions lays the groundwork for enhanced voluntary control of behavior during cognitive development.",

keywords = "Cerebellum, Eye movements, Inhibition, Neuroimaging",

author = "Beatriz Luna and Thulborn, {Keith R.} and Munoz, {Douglas P.} and Merriam, {Elisha P.} and Garver, {Krista E.} and Minshew, {Nancy J.} and Keshavan, {Matcheri S.} and Genovese, {Christopher R.} and Eddy, {William F.} and Sweeney, {John A.}",

note = "Funding Information: This study was supported by MH01727, MH01433, NARSAD, HD35469, NS35949, and MH45156. We thank the staff at the Neu-robehavioral Studies program and UPMC MR Center for assistance in testing subjects. We thank Dawn Boarts for assistance in recruitment and testing of subjects. We also thank Drs. David Kupfer and David Lewis for valuable comments on the findings reported in this manuscript.",

year = "2001",

doi = "10.1006/nimg.2000.0743",

language = "English (US)",

volume = "13",

pages = "786--793",

journal = "NeuroImage",

issn = "1053-8119",

publisher = "Academic Press Inc.",

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T1 - Maturation of widely distributed brain function subserves cognitive development

AU - Luna, Beatriz

AU - Thulborn, Keith R.

AU - Munoz, Douglas P.

AU - Merriam, Elisha P.

AU - Garver, Krista E.

AU - Minshew, Nancy J.

AU - Keshavan, Matcheri S.

AU - Genovese, Christopher R.

AU - Eddy, William F.

AU - Sweeney, John A.

N1 - Funding Information: This study was supported by MH01727, MH01433, NARSAD, HD35469, NS35949, and MH45156. We thank the staff at the Neu-robehavioral Studies program and UPMC MR Center for assistance in testing subjects. We thank Dawn Boarts for assistance in recruitment and testing of subjects. We also thank Drs. David Kupfer and David Lewis for valuable comments on the findings reported in this manuscript.

PY - 2001

Y1 - 2001

N2 - Cognitive and brain maturational changes continue throughout late childhood and adolescence. During this time, increasing cognitive control over behavior enhances the voluntary suppression of reflexive/impulsive response tendencies. Recently, with the advent of functional MRI, it has become possible to characterize changes in brain activity during cognitive development. In order to investigate the cognitive and brain maturation subserving the ability to voluntarily suppress context-inappropriate behavior, we tested 8-30 year olds in an oculomotor response-suppression task. Behavioral results indicated that adult-like ability to inhibit prepotent responses matured gradually through childhood and adolescence. Functional MRI results indicated that brain activation in frontal, parietal, striatal, and thalamic regions increased progressively from childhood to adulthood. Prefrontal cortex was more active in adolescents than in children or adults; adults demonstrated greater activation in the lateral cerebellum than younger subjects. These results suggest that efficient top-down modulation of reflexive acts may not be fully developed until adulthood and provide evidence that maturation of function across widely distributed brain regions lays the groundwork for enhanced voluntary control of behavior during cognitive development.

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KW - Inhibition

KW - Neuroimaging

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Maturation of widely distributed brain function subserves cognitive development

Abstract

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