maxPET: A dedicated mammary and axillary region PET imaging system for breast cancer

N. K. Doshi; R. W. Silverman; Y. Shao; S. R. Cherry

doi:10.1109/23.940168

maxPET: A dedicated mammary and axillary region PET imaging system for breast cancer

N. K. Doshi, R. W. Silverman, Y. Shao, S. R. Cherry

Research output: Contribution to journal › Conference article › peer-review

69 Scopus citations

Abstract

In this paper, we present initial measurements from a high-performance prototype dedicated PET camera (maxPET) designed for mammary and axillary region imaging. The system consists of two 15×15 cm² planar scintillation detector plates operating in coincidence, with each plate composed of 25 modular detectors. The modular detectors are comprised of a 9×9 array of 3 ×3×20 mm³ lutetium oxyorthosilicate (LSO) detector elements, read out by a position-sensitive photomultiplier tube (PS-PMT). A multiplexing readout scheme is used to reduce the number of readout channels from 200 (4X and 4Y readouts per PS-PMT) to 8 channels per plate. The detectors have a measured intrinsic spatial resolution of 2.3 mm. Over 95% of the 4050 crystals in the system can be identified in flood histograms of the detector plates. The coincidence timing resolution for the entire system is 8.1 ns. A line source phantom was scanned with the system and images reconstructed using focal plane tomography. The estimated resolution in projection images is 4 mm based on profiles taken through the line source phantom images. The goal of the maxPET system will be to aid in breast cancer patient management by assisting in imaging women with dense fibro-glandular breasts, detecting axillary lymph node metastases without surgery, and monitoring chemotherapy effectiveness. Future research on the maxPET system will focus on changes to the electronics to improve count rate performance and timing resolution and the mounting of the detectors on a rotating gantry for tomographic studies.

Original language	English (US)
Pages (from-to)	811-815
Number of pages	5
Journal	IEEE Transactions on Nuclear Science
Volume	48
Issue number	3 II
DOIs	https://doi.org/10.1109/23.940168
State	Published - Jun 2001
Event	2000 Medical Imaging Conference (MIC) - Lyon, France Duration: Oct 15 2000 → Oct 20 2000

Keywords

Breast cancer
FDG
Fiber optic tapers
Imaging detectors
LSO
Positron emission tomography (PET)

ASJC Scopus subject areas

Nuclear and High Energy Physics
Nuclear Energy and Engineering
Electrical and Electronic Engineering

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10.1109/23.940168

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@article{83b8627ebda34ee3973faf6fa353ead0,

title = "maxPET: A dedicated mammary and axillary region PET imaging system for breast cancer",

abstract = "In this paper, we present initial measurements from a high-performance prototype dedicated PET camera (maxPET) designed for mammary and axillary region imaging. The system consists of two 15×15 cm2 planar scintillation detector plates operating in coincidence, with each plate composed of 25 modular detectors. The modular detectors are comprised of a 9×9 array of 3 ×3×20 mm3 lutetium oxyorthosilicate (LSO) detector elements, read out by a position-sensitive photomultiplier tube (PS-PMT). A multiplexing readout scheme is used to reduce the number of readout channels from 200 (4X and 4Y readouts per PS-PMT) to 8 channels per plate. The detectors have a measured intrinsic spatial resolution of 2.3 mm. Over 95% of the 4050 crystals in the system can be identified in flood histograms of the detector plates. The coincidence timing resolution for the entire system is 8.1 ns. A line source phantom was scanned with the system and images reconstructed using focal plane tomography. The estimated resolution in projection images is 4 mm based on profiles taken through the line source phantom images. The goal of the maxPET system will be to aid in breast cancer patient management by assisting in imaging women with dense fibro-glandular breasts, detecting axillary lymph node metastases without surgery, and monitoring chemotherapy effectiveness. Future research on the maxPET system will focus on changes to the electronics to improve count rate performance and timing resolution and the mounting of the detectors on a rotating gantry for tomographic studies.",

keywords = "Breast cancer, FDG, Fiber optic tapers, Imaging detectors, LSO, Positron emission tomography (PET)",

author = "Doshi, {N. K.} and Silverman, {R. W.} and Y. Shao and Cherry, {S. R.}",

note = "Funding Information: Manuscript received December 15, 2000; revised March 23, 2001. This work was supported in part by the U.S. Army under Grant DAMD17-96-1-6200, California Breast Cancer Research Training under Grant 513408-18071, and Komen Foundation under Grant 99-003015. The authors are with the Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, CA 90095-1770 USA. Publisher Item Identifier S 0018-9499(01)05094-8.; 2000 Medical Imaging Conference (MIC) ; Conference date: 15-10-2000 Through 20-10-2000",

year = "2001",

month = jun,

doi = "10.1109/23.940168",

language = "English (US)",

volume = "48",

pages = "811--815",

journal = "IEEE Transactions on Nuclear Science",

issn = "0018-9499",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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TY - JOUR

T1 - maxPET

T2 - 2000 Medical Imaging Conference (MIC)

AU - Doshi, N. K.

AU - Silverman, R. W.

AU - Shao, Y.

AU - Cherry, S. R.

N1 - Funding Information: Manuscript received December 15, 2000; revised March 23, 2001. This work was supported in part by the U.S. Army under Grant DAMD17-96-1-6200, California Breast Cancer Research Training under Grant 513408-18071, and Komen Foundation under Grant 99-003015. The authors are with the Crump Institute for Molecular Imaging, UCLA School of Medicine, Los Angeles, CA 90095-1770 USA. Publisher Item Identifier S 0018-9499(01)05094-8.

PY - 2001/6

Y1 - 2001/6

N2 - In this paper, we present initial measurements from a high-performance prototype dedicated PET camera (maxPET) designed for mammary and axillary region imaging. The system consists of two 15×15 cm2 planar scintillation detector plates operating in coincidence, with each plate composed of 25 modular detectors. The modular detectors are comprised of a 9×9 array of 3 ×3×20 mm3 lutetium oxyorthosilicate (LSO) detector elements, read out by a position-sensitive photomultiplier tube (PS-PMT). A multiplexing readout scheme is used to reduce the number of readout channels from 200 (4X and 4Y readouts per PS-PMT) to 8 channels per plate. The detectors have a measured intrinsic spatial resolution of 2.3 mm. Over 95% of the 4050 crystals in the system can be identified in flood histograms of the detector plates. The coincidence timing resolution for the entire system is 8.1 ns. A line source phantom was scanned with the system and images reconstructed using focal plane tomography. The estimated resolution in projection images is 4 mm based on profiles taken through the line source phantom images. The goal of the maxPET system will be to aid in breast cancer patient management by assisting in imaging women with dense fibro-glandular breasts, detecting axillary lymph node metastases without surgery, and monitoring chemotherapy effectiveness. Future research on the maxPET system will focus on changes to the electronics to improve count rate performance and timing resolution and the mounting of the detectors on a rotating gantry for tomographic studies.

AB - In this paper, we present initial measurements from a high-performance prototype dedicated PET camera (maxPET) designed for mammary and axillary region imaging. The system consists of two 15×15 cm2 planar scintillation detector plates operating in coincidence, with each plate composed of 25 modular detectors. The modular detectors are comprised of a 9×9 array of 3 ×3×20 mm3 lutetium oxyorthosilicate (LSO) detector elements, read out by a position-sensitive photomultiplier tube (PS-PMT). A multiplexing readout scheme is used to reduce the number of readout channels from 200 (4X and 4Y readouts per PS-PMT) to 8 channels per plate. The detectors have a measured intrinsic spatial resolution of 2.3 mm. Over 95% of the 4050 crystals in the system can be identified in flood histograms of the detector plates. The coincidence timing resolution for the entire system is 8.1 ns. A line source phantom was scanned with the system and images reconstructed using focal plane tomography. The estimated resolution in projection images is 4 mm based on profiles taken through the line source phantom images. The goal of the maxPET system will be to aid in breast cancer patient management by assisting in imaging women with dense fibro-glandular breasts, detecting axillary lymph node metastases without surgery, and monitoring chemotherapy effectiveness. Future research on the maxPET system will focus on changes to the electronics to improve count rate performance and timing resolution and the mounting of the detectors on a rotating gantry for tomographic studies.

KW - Breast cancer

KW - FDG

KW - Fiber optic tapers

KW - Imaging detectors

KW - LSO

KW - Positron emission tomography (PET)

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U2 - 10.1109/23.940168

DO - 10.1109/23.940168

M3 - Conference article

AN - SCOPUS:0035355148

SN - 0018-9499

VL - 48

SP - 811

EP - 815

JO - IEEE Transactions on Nuclear Science

JF - IEEE Transactions on Nuclear Science

IS - 3 II

Y2 - 15 October 2000 through 20 October 2000

ER -

maxPET: A dedicated mammary and axillary region PET imaging system for breast cancer

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