MDCT of extranodal mantle cell lymphoma: a single institute experience

Akshay D. Baheti, Sree Harsha Tirumani, Rani Sewatkar, Saboo S. Sachin, Atul B. Shinagare, Nikhil H. Ramaiya

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To study the pattern of extranodal and particularly gastrointestinal (GI) involvement of mantle cell lymphoma (MCL) on MDCT Materials and methods: In this IRB-approved, HIPAA compliant retrospective study, MDCT features of 78 patients (62 males and 16 females, mean age 57 years) with MCL including 28 patients at presentation were reviewed. Clinical and histopathological (blastoid vs. non-blastoid) data were noted from medical records. Results: Extranodal involvement was present in overall 51/78 patients on CT (65%), 18/28 (64%) patients at presentation. Spleen (21/78–27%) and bowel (19/78–24%) were the most common sites of extranodal involvement by MCL on imaging, followed by lungs (10/78–13%) and skin/subcutaneous tissue (9/78–12%). Bowel involvement was either in the form of endophytic polypoidal lesions (n = 11, mean size 3.1 cm), as focal mild bowel wall thickening (n = 5, mean thickness 1.4 cm), or as combination of the two (n = 3). Blastoid histology was present in 14/78 (24%) patients and was statistically associated with skin/subcutaneous involvement (p < 0.05; Fisher’s exact t test). Median follow-up was 72 months during which 21 patients died with median survival of 48 months (26 months for blastoid histology vs. 47 months for non-blastoid histology). There was no statistical correlation between sites of involvement and survival. Conclusions: MCL has a predilection for extranodal disease, predominantly involving the spleen, bowel, lungs, and subcutaneous tissue. GI involvement on CT is in the form of endoluminal polypoidal lesions and mild bowel wall thickening. Skin/subcutaneous involvement was statistically more common with blastoid histology in our study.

Original languageEnglish (US)
Pages (from-to)1693-1699
Number of pages7
JournalAbdominal Imaging
Volume40
Issue number6
DOIs
StatePublished - Aug 12 2015

Fingerprint

Mantle-Cell Lymphoma
Histology
Subcutaneous Tissue
Skin
Spleen
Health Insurance Portability and Accountability Act
Lung
Survival
Research Ethics Committees
Medical Records
Retrospective Studies

Keywords

  • CT
  • Extranodal
  • Gastrointestinal
  • GI
  • Mantle cell lymphoma

ASJC Scopus subject areas

  • Gastroenterology
  • Urology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Baheti, A. D., Tirumani, S. H., Sewatkar, R., Sachin, S. S., Shinagare, A. B., & Ramaiya, N. H. (2015). MDCT of extranodal mantle cell lymphoma: a single institute experience. Abdominal Imaging, 40(6), 1693-1699. https://doi.org/10.1007/s00261-015-0389-9

MDCT of extranodal mantle cell lymphoma : a single institute experience. / Baheti, Akshay D.; Tirumani, Sree Harsha; Sewatkar, Rani; Sachin, Saboo S.; Shinagare, Atul B.; Ramaiya, Nikhil H.

In: Abdominal Imaging, Vol. 40, No. 6, 12.08.2015, p. 1693-1699.

Research output: Contribution to journalArticle

Baheti, AD, Tirumani, SH, Sewatkar, R, Sachin, SS, Shinagare, AB & Ramaiya, NH 2015, 'MDCT of extranodal mantle cell lymphoma: a single institute experience', Abdominal Imaging, vol. 40, no. 6, pp. 1693-1699. https://doi.org/10.1007/s00261-015-0389-9
Baheti AD, Tirumani SH, Sewatkar R, Sachin SS, Shinagare AB, Ramaiya NH. MDCT of extranodal mantle cell lymphoma: a single institute experience. Abdominal Imaging. 2015 Aug 12;40(6):1693-1699. https://doi.org/10.1007/s00261-015-0389-9
Baheti, Akshay D. ; Tirumani, Sree Harsha ; Sewatkar, Rani ; Sachin, Saboo S. ; Shinagare, Atul B. ; Ramaiya, Nikhil H. / MDCT of extranodal mantle cell lymphoma : a single institute experience. In: Abdominal Imaging. 2015 ; Vol. 40, No. 6. pp. 1693-1699.
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abstract = "Objective: To study the pattern of extranodal and particularly gastrointestinal (GI) involvement of mantle cell lymphoma (MCL) on MDCT Materials and methods: In this IRB-approved, HIPAA compliant retrospective study, MDCT features of 78 patients (62 males and 16 females, mean age 57 years) with MCL including 28 patients at presentation were reviewed. Clinical and histopathological (blastoid vs. non-blastoid) data were noted from medical records. Results: Extranodal involvement was present in overall 51/78 patients on CT (65{\%}), 18/28 (64{\%}) patients at presentation. Spleen (21/78–27{\%}) and bowel (19/78–24{\%}) were the most common sites of extranodal involvement by MCL on imaging, followed by lungs (10/78–13{\%}) and skin/subcutaneous tissue (9/78–12{\%}). Bowel involvement was either in the form of endophytic polypoidal lesions (n = 11, mean size 3.1 cm), as focal mild bowel wall thickening (n = 5, mean thickness 1.4 cm), or as combination of the two (n = 3). Blastoid histology was present in 14/78 (24{\%}) patients and was statistically associated with skin/subcutaneous involvement (p < 0.05; Fisher’s exact t test). Median follow-up was 72 months during which 21 patients died with median survival of 48 months (26 months for blastoid histology vs. 47 months for non-blastoid histology). There was no statistical correlation between sites of involvement and survival. Conclusions: MCL has a predilection for extranodal disease, predominantly involving the spleen, bowel, lungs, and subcutaneous tissue. GI involvement on CT is in the form of endoluminal polypoidal lesions and mild bowel wall thickening. Skin/subcutaneous involvement was statistically more common with blastoid histology in our study.",
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AU - Shinagare, Atul B.

AU - Ramaiya, Nikhil H.

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AB - Objective: To study the pattern of extranodal and particularly gastrointestinal (GI) involvement of mantle cell lymphoma (MCL) on MDCT Materials and methods: In this IRB-approved, HIPAA compliant retrospective study, MDCT features of 78 patients (62 males and 16 females, mean age 57 years) with MCL including 28 patients at presentation were reviewed. Clinical and histopathological (blastoid vs. non-blastoid) data were noted from medical records. Results: Extranodal involvement was present in overall 51/78 patients on CT (65%), 18/28 (64%) patients at presentation. Spleen (21/78–27%) and bowel (19/78–24%) were the most common sites of extranodal involvement by MCL on imaging, followed by lungs (10/78–13%) and skin/subcutaneous tissue (9/78–12%). Bowel involvement was either in the form of endophytic polypoidal lesions (n = 11, mean size 3.1 cm), as focal mild bowel wall thickening (n = 5, mean thickness 1.4 cm), or as combination of the two (n = 3). Blastoid histology was present in 14/78 (24%) patients and was statistically associated with skin/subcutaneous involvement (p < 0.05; Fisher’s exact t test). Median follow-up was 72 months during which 21 patients died with median survival of 48 months (26 months for blastoid histology vs. 47 months for non-blastoid histology). There was no statistical correlation between sites of involvement and survival. Conclusions: MCL has a predilection for extranodal disease, predominantly involving the spleen, bowel, lungs, and subcutaneous tissue. GI involvement on CT is in the form of endoluminal polypoidal lesions and mild bowel wall thickening. Skin/subcutaneous involvement was statistically more common with blastoid histology in our study.

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